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Indian J Pharmacol. 2019 Mar-Apr;51(2):88-92. doi: 10.4103/ijp.IJP_183_18.

Wound healing effects of topical Vitamin K: A randomized controlled trial.

Author information

1
Department of Dermatology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
2
Department of Pharmacology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
3
Department of Pharmacology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
4
Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
5
Department of Pharmacology, School of Medicine, Dezful University of Medical Sciences, Dezful, Iran.

Abstract

BACKGROUND:

The incidence of acute and chronic wounds has rapidly increased which treatment remains as health problem. Previously, we reported the healing effect of Vitamin K in experimental animal models. The aim of this study was to investigate the effects of topical Vitamin K on skin wound healing process in patients.

MATERIALS AND METHODS:

Sixty-three patients with indication for high-frequency electrocautery were enrolled in this randomized controlled trial. The patients were divided randomly into three groups. All the patients underwent high-frequency electrocautery treatment. Then, the patients in the A group received 1% Vitamin K cream, the patients in the B group received 1% phenytoin cream. Furthermore, the patients in the control group received Eucerin. The wound status (width and the time of recovery) and complications in the three groups were evaluated 2 weeks after procedure by a dermatologist.

RESULTS:

The effects produced by the topical Vitamin K showed a significant (P < 0.05) healing when compared with Eucerin group in parameters such as wound contraction and time to full recovery. Moreover, the healing time did not differ between phenytoin and Vitamin K groups (P = 0.16).

CONCLUSION:

A randomized, controlled trial suggests that topical application of Vitamin K significantly reduces healing time in patients.

KEYWORDS:

Phenytoin; Vitamin K; skin; topical application; wound healing

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