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Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11894-11899. doi: 10.1073/pnas.1820469116. Epub 2019 May 29.

Role of thyroid dysimmunity and thyroid hormones in endometriosis.

Author information

1
Institut Cochin, INSERM U1016, Université Paris Descartes, Sorbonne Paris Cité, 75679 Paris, France.
2
Assistance Publique-Hôpitaux de Paris, Hôpital Universitaire Paris Centre, Centre Hospitalier Universitaire Cochin, 75679 Paris, France.
3
Service d'immunologie biologique, Université Paris Descartes, Sorbonne Paris Cité, 75679 Paris, France.
4
HKU Pasteur Research Pole, School of Public Health, The University of Hong Kong, Hong Kong, China.
5
Département d'Information Médicale, Université Paris Descartes, Sorbonne Paris Cité, 75679 Paris, France.
6
Service de Diagnostic Biologique Automatisé, Université Paris Descartes, Sorbonne Paris Cité, 75679 Paris, France.
7
Département de Gynécologie Obstétrique II et Médecine de la Reproduction, Université Paris Descartes, Sorbonne Paris Cité, 75679 Paris, France.
8
Institut Cochin, INSERM U1016, Université Paris Descartes, Sorbonne Paris Cité, 75679 Paris, France; frederic.batteux@aphp.fr.

Abstract

Endometriosis is characterized by the presence of ectopic endometrial cells outside the uterine cavity. Thyroid autoimmunity has been associated with endometriosis. This work investigated the potential pathophysiological link between endometriosis and thyroid disorders. Transcripts and proteins involved in thyroid metabolism are dysregulated in eutopic and ectopic endometrium of endometriotic patients, leading to resistance of ectopic endometrium to triiodothyronine (T3) action and local accumulation of thyroxine (T4). Thyroid-stimulating hormone (TSH) acts as a proliferative and prooxidative hormone on all endometria of endometriosis patients and controls, whereas T3 and T4 act to specifically increase ectopic endometrial cell proliferation and reactive oxygen species (ROS) production. Mouse studies confirmed the data gained in vitro since endometriotic implants were found to be bigger when thyroid hormones increased. A retrospective analysis of endometriosis patients with or without a thyroid disorder revealed an increased chronic pelvic pain and disease score in endometriotic patients with a thyroid disorder.

KEYWORDS:

autoimmunity; endometriosis; oxidative stress; thyroid; thyroid hormones

PMID:
31142643
DOI:
10.1073/pnas.1820469116

Conflict of interest statement

The authors declare no conflict of interest.

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