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Arq Gastroenterol. 2019 May 20;56(1):88-94. doi: 10.1590/S0004-2803.201900000-20.

ASSOCIATION OF TNF- α-308G>A POLYMORPHISM WITH SUSCEPTIBILITY TO CELIAC DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS.

Author information

1
Shahid Sadoughi University of Medical Sciences, Department of Pediatrics, Yazd, Iran.
2
Shahid Sadoughi University of Medical Sciences, Department of Pathology, Yazd, Iran.
3
Bam University of Medical Sciences, Department of Healthcare Management, Bam, Iran.
4
Ardakan University, Faculty of Veterinary Medicine, Department of Basic Science, Ardakan, Iran.
5
Shahid Sadoughi University of Medical Sciences, Department of Anesthesiology and Critical Care, Yazd, Iran.
6
Shahid Sadoughi University of Medical Sciences, Department of Medical Genetics, Yazd, Iran.

Abstract

BACKGROUND:

There is increasing evidence to show that TNF-α -308G>A polymorphism may be a risk factor for celiac disease, but the results are inconsistent.

OBJECTIVE:

Thus, we aimed to perform a meta-analysis involving published studies up to January 2019 to elucidate the association.

METHODS:

To assess the effect of TNF-α -308G>A polymorphism on celiac disease susceptibility, we searched PubMed, ISI Web of Knowledge, Chinese National Knowledge Infrastructure (CNKI) databases to identify eligible studies, without restriction. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the susceptibility to celiac disease.

RESULTS:

A total of 11 studies with 1147 cases and 1774 controls were selected for this meta-analysis. The pooled results indicated that TNF-α -308G>A polymorphism was associated with increased risk of celiac disease (A vs G: OR=2.077, 95% CI=1.468-2.939, P=≤0.001; AA vs GG: OR=8.512, 95% CI=3.740-19.373, P=≤0.001; AA+AG vs GG: OR=1.869, 95% CI=1.161-3.008, P=0.010; and AA+AG vs GG: OR=4.773, 95% CI=3.181-7.162, P≤0.001). Subgroup analysis by ethnicity also revealed significant association in Caucasians. In addition, there was a significant association between TNF-α -308G>A polymorphism and celiac disease risk in Italy, Spain and PCR-FRLP group studies.

CONCLUSION:

Our meta-analysis suggests that the TNF-α -308G>A polymorphism plays an important role in celiac disease susceptibility. However, our results are still needed to strengthen by further studies in different ethnicities and larger sample sizes.

PMID:
31141070
DOI:
10.1590/S0004-2803.201900000-20
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