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Ann Clin Transl Neurol. 2019 Apr 11;6(5):945-953. doi: 10.1002/acn3.740. eCollection 2019 May.

Clinical significance of soluble adhesion molecules in anti-NMDAR encephalitis patients.

Ding Y1,2, Yang C3,4, Zhou Z4,5, Peng Y1, Chen J1, Pan S1, Xu H4, Cai Y6, Ou K7, Xie W2,8, Wang H1.

Author information

Department of Neurology Nanfang Hospital Southern Medical University Guangzhou China.
School of Traditional Chinese Medicine Southern Medical University Guangzhou China.
Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences Guangdong Mental Health Center Guangzhou China.
The Second School of Clinical Medicine Southern Medical University Guangdong Province China.
Department of Neurology Liuzhou Traditional Chinese Medical Hospital Liuzhou China.
Hexian Memorial Hospital Guangzhou China.
Department of Neurology Laibin People's Hospital Laibin China.
Department of Traditional Chinese Medicine Nanfang Hospital Southern Medical University Guangzhou China.


Increasing evidence indicates that immune system dysfunction affects anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. This study aims to investigate the relationship between adhesion molecules and the pathophysiology in anti-NMDAR encephalitis. Soluble forms of Intercellular adhesion molecule-1 (sICAM-1), vascular adhesion molecule-1 (sVCAM-1), and L-selectin (sL-selectin), were measured in the CSF and serum of 26 participants with anti-NMDAR encephalitis, 11 patients with schizophrenia and 22 patients with noninflammatory disorders. CSF levels of sICAM-1, sVCAM-1 and sL-selectin were significantly elevated in the anti-NMDAR encephalitis group. sVCAM-1 levels were positively associated with modified Rankin scale score in anti-NMDAR encephalitis patients at the onset and 3-month follow-up.

Conflict of interest statement

All authors read and approved the final manuscript. They declare no conflicts of interest.

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