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Nutrients. 2019 May 27;11(5). pii: E1194. doi: 10.3390/nu11051194.

Effect of Vitamin D3 on the Postprandial Lipid Profile in Obese Patients: A Non-Targeted Lipidomics Study.

Author information

1
Universitat Rovira i Virgili, Departament de Medicina i Cirurgia, Unitat de Recerca Biomèdica, C/de l'Escorxador S/N, 43003 Tarragona, Spain. salvador.fernandez@urv.cat.
2
Campus of International Excellence Southern Catalonia, 43003 Tarragona, Spain. salvador.fernandez@urv.cat.
3
Institut d'investigació Sanitària Pere Virgili, C/de l'Escorxador S/N, 43003 Tarragona, Spain. anna.hernandeza@gmail.com.
4
Department of Internal Medicine, Center for Diabetes and Vascular Medicine, Franciscus Gasthuis & Vietland, 3045 PM Rotterdam, The Netherlands. M.deVries@Franciscus.nl.
5
Department of Internal Medicine, Center for Diabetes and Vascular Medicine, Franciscus Gasthuis & Vietland, 3045 PM Rotterdam, The Netherlands. B.Burggraaf@Franciscus.nl.
6
Department of Clinical Chemistry, Franciscus Gasthuis & Vietland, 3045 PM Rotterdam, The Netherlands. E.vanderZwan@Franciscus.nl.
7
Department of Clinical Chemistry, Franciscus Gasthuis & Vietland, 3045 PM Rotterdam, The Netherlands. N.Pouw@Franciscus.nl.
8
Universitat Rovira i Virgili, Departament de Medicina i Cirurgia, Unitat de Recerca Biomèdica, C/de l'Escorxador S/N, 43003 Tarragona, Spain. jorge.joven@urv.cat.
9
Campus of International Excellence Southern Catalonia, 43003 Tarragona, Spain. jorge.joven@urv.cat.
10
Institut d'investigació Sanitària Pere Virgili, C/de l'Escorxador S/N, 43003 Tarragona, Spain. jorge.joven@urv.cat.
11
Department of Internal Medicine, Center for Diabetes and Vascular Medicine, Franciscus Gasthuis & Vietland, 3045 PM Rotterdam, The Netherlands. M.CastroCabezas@Franciscus.nl.

Abstract

Abstract: Postprandial lipemia can lead to an accumulation of atherogenic lipoproteins in the circulation associated with systemic low-grade inflammation and an increased risk of cardiovascular disease. Lifestyle and pharmacological treatments are usually prescribed for prevention. Vitamin D3 (cholecalciferol), as an anti-atherogenic agent, is being taken into consideration due to its potential beneficial effects in lipid metabolism and its anti-inflammatory potency. To assess the effects of vitamin D3 in the postprandial lipid profile in obese, vitamin D-deficient women, a non-targeted lipidomics approach using liquid chromatography coupled to a quadrupole time-of flight mass spectrometer was used to identify and quantitate a wide-range of circulating lipid species, including diglycerides, lysophosphatidylcholines, phosphatidylcholines, phosphatidylethanolamines, sphingomyelins and triglycerides. The most important changes were found in plasmatic sphingomyelin levels, which experience a decrease after vitamin D3 intake. Our results suggest a turnover of sphingomyelins, probably due to an increased activity of neutral sphingomyelinases, and, therefore, with implications in the clearance of chylomicrons, LDL and VLDL, decreasing postprandial inflammation and macrophage adherence to endothelia, potentially improving cardiovascular disease risk.

KEYWORDS:

cholecalciferol; lipid absorption; lipidomics; obesity; postprandial inflammation; sphingomyelin

Conflict of interest statement

Funding: This work was supported by grants to Jorge Joven from the Plan Nacional de I + D + I, Spain, Instituto de Salud Carlos III (PI15/00285 and PI18/00921) co-funded by the European Regional Development Fund (FEDER). We also acknowledge the support of the Fundació la Marató de TV3 and the Agència de Gestió d’Ajuts Universitaris i de Recerca (2017SGR436). Salvador Fernández is currently financed by the Universitat Rovira i Virgili Martí i Franquès grant 2016PMF-POST-02. Financial support was also provided by the Foundation for Research and Development of the Department of Internal Medicine of the Franciscus Gasthuis, Rotterdam, the Netherlands.

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