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Mar Drugs. 2019 May 27;17(5). pii: E311. doi: 10.3390/md17050311.

Anti-Obesity Effect of Standardized Extract of Microalga Phaeodactylum tricornutum Containing Fucoxanthin.

Author information

1
Natural Product Informatics Center, KIST Gangneung Institute of Natural Products, Gangneung 25451, Korea. ninesong2@kist.re.kr.
2
Department of Food and Nutrition, and Research Institute of Human Ecology, Seoul National University, Seoul 08826, Korea. ninesong2@kist.re.kr.
3
Natural Product Informatics Center, KIST Gangneung Institute of Natural Products, Gangneung 25451, Korea. hwangjh@kist.re.kr.
4
Department of Medical Biotechnology, College of Life Science and Biotechnology, Dongguk University, Seoul 04620, Korea. shyang@dongguk.edu.
5
R&D Department, AlgaeTech Co. Ltd., Gangneung 25457, Korea. korea4633@naver.com.
6
R&D Department, AlgaeTech Co. Ltd., Gangneung 25457, Korea. hongtol2@gmail.com.
7
Natural Product Informatics Center, KIST Gangneung Institute of Natural Products, Gangneung 25451, Korea. kskang@kist.re.kr.
8
Division of Bio-Medical Science & Technology, University of Science & Technology, Daejeon 34113, Korea. kskang@kist.re.kr.
9
Natural Product Informatics Center, KIST Gangneung Institute of Natural Products, Gangneung 25451, Korea. panc@kist.re.kr.
10
Division of Bio-Medical Science & Technology, University of Science & Technology, Daejeon 34113, Korea. panc@kist.re.kr.
11
Department of Food and Nutrition, and Research Institute of Human Ecology, Seoul National University, Seoul 08826, Korea. keum@snu.ac.kr.
12
Smart Farm Research Center, KIST Gangneung Institute of Natural Products, Gangneung 25451, Korea. kimsm@kist.re.kr.
13
Division of Bio-Medical Science & Technology, University of Science & Technology, Daejeon 34113, Korea. kimsm@kist.re.kr.

Abstract

Fucoxanthin (FX), a marine carotenoid found in macroalgae and microalgae, exhibits several beneficial effects to health. The anti-obesity activity of FX is well documented, but FX has not been mass-produced or applied extensively or commercially because of limited availability of raw materials and complex extraction techniques. In this study, we investigated the anti-obesity effect of standardized FX powder (Phaeodactylum extract (PE)) developed from microalga Phaeodactylum tricornutum as a commercial functional food. The effects of PE on adipogenesis inhibition in 3T3-L1 adipocytes and anti-obesity in high-fat diet (HFD)-fed C57BL/6J mice were evaluated. PE and FX dose-dependently decreased intracellular lipid contents in adipocytes without cytotoxicity. In HFD-fed obese mice, PE supplementation for six weeks decreased body weight, organ weight, and adipocyte size. In the serum parameter analysis, the PE-treated groups showed attenuation of lipid metabolism dysfunction and liver damage induced by HFD. In the liver, uncoupling protein-1 (UCP1) upregulation and peroxisome proliferator activated receptor γ (PPARγ) downregulation were detected in the PE-treated groups. Additionally, micro computed tomography revealed lower fat accumulation in PE-treated groups compared to that in the HFD group. These results indicate that PE exerts anti-obesity effects by inhibiting adipocytic lipogenesis, inducing fat mass reduction and decreasing intracellular lipid content, adipocyte size, and adipose weight.

KEYWORDS:

Phaeodactylum extract; Phaeodactylum tricornutum; anti-obesity effect; fucoxanthin; microalgae

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