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Exp Clin Endocrinol Diabetes. 2019 May 28. doi: 10.1055/a-0883-4955. [Epub ahead of print]

Altered Brain Regional Homogeneity in First-Degree Relatives of Type 2 Diabetics: A functional MRI Study.

Author information

1
Medical Imaging Center, the First Affiliated Hospital of Jinan University, Guangzhou, China.
2
Department of Imaging and Interventional Radiology, Research Centre for Medical Image Computing, The Chinese University of Hong Kong, China.
3
Chow Yuk Ho Technology Centre for Innovative Medicine, The Chinese University of Hong Kong, China.
4
Department of Rehabilitation, the First Affiliated Hospital of Jinan University, Guangzhou, China.
5
Auckland Bioengineering Institute, and Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
6
Shenzhen SmartView MedTech Limited, Shenzhen, China.

Abstract

OBJECTIVE:

This study aimed to investigate regional homogeneity in the first-: degree relatives of type 2 diabetes patients.

METHODS:

Seventy-eight subjects, including 26 type 2 diabetes patients, 26 first-: degree relatives, and 26 healthy controls, were assessed. All participants underwent resting-state functional magnetic resonance imaging scanning. The estimated regional homogeneity value was used to evaluate differences in brain activities.

RESULTS:

In first-: degree relatives, we observed significantly decreased regional homogeneity in the left anterior cingulate cortex, left insula, and bilateral temporal lobes, and increased regional homogeneity in the left superior frontal gyrus, right anterior cingulate cortex, and bilateral posterior cingulate cortex compared to healthy controls. In type 2 diabetes patients, we detected altered regional homogeneity in the left anterior cingulate cortex, left insula, bilateral posterior cingulate cortex, and several other brain regions compared to healthy controls. Both first-: degree relatives and type 2 diabetes patients showed decreased regional homogeneity in the left superior temporal gyrus, right middle temporal gyrus, left anterior cingulate cortex, left insula, and increased regional homogeneity in the left superior frontal gyrus and bilateral posterior cingulate cortex.

CONCLUSION:

These findings suggest that altered regional homogeneity in the left anterior cingulate cortex, left insula, left superior frontal gyrus, bilateral posterior cingulate cortex, and bilateral temporal lobes might be a neuroimaging biomarker of type 2 diabetes -: related brain dysfunction.

PMID:
31137069
DOI:
10.1055/a-0883-4955

Conflict of interest statement

The authors declare that they have no conflict of interest.

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