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PLoS Biol. 2019 May 28;17(5):e3000285. doi: 10.1371/journal.pbio.3000285. eCollection 2019 May.

Surviving starvation simply without TFEB.

Soukas AA1,2,3, Zhou B1,2,3.

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Department of Medicine, Diabetes Unit, and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.
Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America.


Starvation is among the most ancient of selection pressures, driving evolution of a robust arsenal of starvation survival defenses. In order to survive starvation stress, organisms must be able to curtail anabolic processes during starvation and judiciously activate catabolic pathways. Although the activation of metabolic defenses in response to nutrient deprivation is an obvious component of starvation survival, less appreciated is the importance of the ability to recover from starvation upon re-exposure to nutrients. In order for organisms to successfully recover from starvation, cells must be kept in a state of ready so that upon the return of nutrients, activities such as growth and reproduction can be resumed. Critical to this state of ready is the lysosome, an organelle that provides essential signals of nutrient sufficiency to cell growth-activating pathways in the fed state. In this issue, Murphy and colleagues provide evidence that exposure of Caenorhabditis elegans roundworms to 2 simple nutrients, glucose and the polyunsaturated fatty acid linoleate, is able to render lysosomal function competent to activate key downstream starvation recovery pathways, bypassing the need for a master transcriptional regulator of lysosomes. These findings provide a quantum leap forward in our understanding of the cellular determinants that permit organisms to survive cycles of feast and famine.

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