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J Basic Clin Physiol Pharmacol. 2019 May 28;30(3). pii: /j/jbcpp.2019.30.issue-3/jbcpp-2018-0150/jbcpp-2018-0150.xml. doi: 10.1515/jbcpp-2018-0150.

Accelerated wound healing process in rat by probiotic Lactobacillus reuteri derived ointment.

Author information

1
Dietary Supplements and Probiotic Research Center, Alborz University of Medical Sciences, Eshteraki Blvd. Baghestan, Karaj 9779453, Iran, Phone: +98 2634336007, Fax:+98 2634319188.
2
Department of Biochemistry, Genetics and Nutrition, Faculty of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
3
Student Research Committee, Faculty of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
4
Department of Pathology, Faculty of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
5
Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abstract

Background Antioxidant agents have positive effects on wound healing process and on the other hand probiotics also have great antioxidation or oxidation-resistance properties. Methods In this study, we investigated the effects of Lactobacillus reuteri derived ointment as a probiotic bacterium on the wound healing process using a full-thickness rat skin model. The wound diameter and contraction percent measurement, histopathological examination, and myeloperoxidase (MPO) enzyme activity evaluation were carried out during the period of study. Results Amount of deposit collagen was significantly increased; epithelization speed and epidermis production were also observed in the ointment-treated group, while the inflammation rate was also significantly lower than the control group. In addition, a significant reduction in the activity of enzyme MPO was also detected in the ointment-treated group. Conclusions According to the results, probiotic ointment effectively accelerates the wound healing process and it can be used as a promising drug for wound dressing application.

KEYWORDS:

Lactobacillus reuteris; histopathology; myeloperoxidase (MPO); probiotics; wound healing

PMID:
31136300
DOI:
10.1515/jbcpp-2018-0150

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