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Nutr Rev. 2019 May 28. pii: nuz023. doi: 10.1093/nutrit/nuz023. [Epub ahead of print]

Effect of saffron supplementation on symptoms of depression and anxiety: a systematic review and meta-analysis.

Author information

1
Food & Mood Centre, IMPACT SRC, School of Medicine, Deakin University, Geelong, Australia.
2
Department of Psychiatry, Kuopio University Hospital, Kuopio, Finland, and the Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
3
School of Psychology and Exercise Science, Murdoch University, Perth, Western Australia, Australia.
4
Faculty of Health Sciences & Medicine, Bond University, Robina, Queensland, Australia.
5
IMPACT SRC, School of Medicine, Barwon Health, Deakin University, Geelong, Australia.
6
Department of Psychiatry, University of Melbourne, Melbourne, Australia, and Orygen, the National Centre of Excellence in Youth Mental Health, Centre for Youth Mental Health and the Florey Institute for Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia.
7
Centre for Adolescent Health, Murdoch Children's Research Institute, Victoria, Australia, and the Black Dog Institute, New South Wales, Australia.
8
Florey Institute for Neuroscience and Mental Health, and the Department of Psychiatry, University of Melbourne, Parkville, Australia.

Abstract

CONTEXT:

Saffron (Crocus sativus L.) has gained interest as a potential treatment in psychiatry.

OBJECTIVE:

This systematic review and meta-analysis sought to investigate the effect of saffron supplementation, as both an adjunctive therapy and monotherapy, on symptoms of depression and anxiety in clinical and general populations compared with pharmacotherapy or placebo.

DATA SOURCES:

Using the PRISMA guidelines, a systematic literature review of randomized controlled trials was conducted.

DATA EXTRACTION:

A meta-analysis was conducted to determine treatment effect. Risk of bias was assessed using the Jadad scale.

RESULTS:

Twenty-three studies were included. Saffron had a large positive effect size when compared with placebo for depressive symptoms (g = 0.99, P < 0.001) and anxiety symptoms (g = 0.95, P < 0.006). Saffron also had a large positive effect size when used as an adjunct to antidepressants for depressive symptoms (g = 1.23, P = 0.028). Egger's regression test found evidence of publication bias.

CONCLUSIONS:

Saffron could be an effective intervention for symptoms of depression and anxiety; however, due to evidence of publication bias and lack of regional diversity, further trials are required. PROSPERO registration CRD42017070060.

KEYWORDS:

depression; herbal medicine; inflammation; mental health; mood disorder; nutraceutical; saffron; treatment

PMID:
31135916
DOI:
10.1093/nutrit/nuz023

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