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J Org Chem. 2019 Jun 21;84(12):8232-8241. doi: 10.1021/acs.joc.9b00506. Epub 2019 Jun 5.

Double-Oxidative Dehydrogenative [4+2]-Cyclization/Dehydrogenation/Oxygenation Tandem Reaction of N-Arylglycine Derivatives with Cumenes.

Author information

1
Key Laboratory of Eco-Environment-Related Polymer Materials, Ministry of Education, College of Chemistry and Chemical Engineering , Northwest Normal University , Lanzhou , Gansu 730070 , China.

Abstract

Double-oxidative dehydrogenative (DOD) cyclization is one of the most straightforward strategies for the synthesis of cyclic compounds. A novel approach to substituted 3,4-dihydroquinoline-3-one derivatives via a Cu(II)/DDQ/O2 system-catalyzed DOD [4+2]-cyclization/dehydrogenation/oxygenation cascade reaction of N-arylglycine derivatives, cumenes, and O2 has been developed.

PMID:
31135157
DOI:
10.1021/acs.joc.9b00506

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