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Trends Genet. 2019 Jul;35(7):501-514. doi: 10.1016/j.tig.2019.04.003. Epub 2019 May 24.

High-Diversity Mouse Populations for Complex Traits.

Author information

1
The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, USA.
2
The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, USA; UNC Chapel Hill, Chapel Hill, NC, USA; SUNY Binghamton, Binghamton, NY, USA; Pittsburgh University, Pittsburgh, PA, USA.
3
The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, USA. Electronic address: elissa.chesler@jax.org.

Abstract

Contemporary mouse genetic reference populations are a powerful platform to discover complex disease mechanisms. Advanced high-diversity mouse populations include the Collaborative Cross (CC) strains, Diversity Outbred (DO) stock, and their isogenic founder strains. When used in systems genetics and integrative genomics analyses, these populations efficiently harnesses known genetic variation for precise and contextualized identification of complex disease mechanisms. Extensive genetic, genomic, and phenotypic data are already available for these high-diversity mouse populations and a growing suite of data analysis tools have been developed to support research on diverse mice. This integrated resource can be used to discover and evaluate disease mechanisms relevant across species.

KEYWORDS:

complex genetics; complex traits; genetic diversity; mouse; systems genetics

PMID:
31133439
PMCID:
PMC6571031
[Available on 2020-07-01]
DOI:
10.1016/j.tig.2019.04.003
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