Format

Send to

Choose Destination
J Neuroeng Rehabil. 2019 May 27;16(1):60. doi: 10.1186/s12984-019-0538-4.

Human translingual neurostimulation alters resting brain activity in high-density EEG.

Author information

1
HealthTech Connex, Surrey, British Columbia, Canada.
2
Pavlov Institute of Physiology, Russian Academy of Science, Sankt Petersburg, Russia.
3
Helius Medical Technologies, Newtown, PA, USA.
4
Oxford University, Oxford, UK.
5
HealthTech Connex, Surrey, British Columbia, Canada. ryan@healthtechconnex.com.

Abstract

BACKGROUND:

Despite growing evidence of a critical link between neuromodulation technologies and neuroplastic recovery, the underlying mechanisms of these technologies remain elusive.

OBJECTIVE:

To investigate physiological evidence of central nervous system (CNS) changes in humans during translingual neurostimulation (TLNS).

METHODS:

We used high-density electroencephalography (EEG) to measure changes in resting brain activity before, during, and after high frequency (HF) and low frequency (LF) TLNS.

RESULTS:

Wavelet power analysis around Cz and microstate analysis revealed significant changes after 20 min of stimulation compared to baseline. A secondary effect of exposure order was also identified, indicating a differential neuromodulatory influence of HF TLNS relative to LF TLNS on alpha and theta signal power.

CONCLUSIONS:

These results further our understanding of the effects of TLNS on underlying resting brain activity, which in the long-term may contribute to the critical link between clinical effect and changes in brain activity.

KEYWORDS:

Cranial nerve stimulation; EEG; Neuromodulation; Neuroplasticity

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center