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Environ Int. 2019 Aug;129:221-228. doi: 10.1016/j.envint.2019.05.030. Epub 2019 May 24.

Persistent organic pollutants and the incidence of type 2 diabetes in the CARLA and KORA cohort studies.

Author information

1
Institute of Epidemiology, Helmholtz Zentrum München, Germany; German Center for Diabetes Research (DZD), München-Neuherberg, Germany. Electronic address: kathrin.wolf@helmholtz-muenchen.de.
2
German Center for Diabetes Research (DZD), München-Neuherberg, Germany; Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Germany.
3
Institute of Epidemiology, Helmholtz Zentrum München, Germany; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.
4
Chair of Epidemiology, LMU Munich, UNIKA-T Augsburg, Germany.
5
Institute of Epidemiology, Helmholtz Zentrum München, Germany.
6
Former: Department of Hygiene, Social and Environmental Medicine, Ruhr-University Bochum, Germany.
7
Molecular EXposomics, Helmholtz Zentrum München, Germany.
8
German Center for Diabetes Research (DZD), München-Neuherberg, Germany; Institute of Medical Epidemiology, Biostatistics, and Informatics, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
9
German Center for Diabetes Research (DZD), München-Neuherberg, Germany; Institute of Medical Epidemiology, Biostatistics, and Informatics, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
10
German Center for Diabetes Research (DZD), München-Neuherberg, Germany; Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Germany; Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.

Abstract

BACKGROUND:

Associations between several persistent organic pollutants (POPs) and type 2 diabetes have been found in humans, but the relationship has rarely been investigated in the general population. The current nested case-control study examined internal exposure to polychlorinated biphenyls (PCB) and pesticides and the incidence of type 2 diabetes among participants of two population-based German cohort studies.

METHODS:

We retrospectively selected 132 incident cases of type 2 diabetes and 264 age- and sex-matched controls from the CARdiovascular Living and Aging in Halle (CARLA) study (2002-2006, East Germany) and the Cooperative Health Research in the Region of Augsburg (KORA) study (1999-2001, South Germany) based on diabetes status at follow-up examinations in 2007-2010 and 2006-08, respectively (60% male, mean age 63 and 54 years). We assessed the association between baseline POP concentrations and incident diabetes by conditional logistic regression adjusted for cohort, BMI, cholesterol, alcohol, smoking, physical activity, and parental diabetes. Additionally, we examined effect modification by sex, obesity, parental diabetes and cohort.

RESULTS:

In both cohorts, diabetes cases showed a higher BMI, a higher frequency of parental diabetes, and higher levels of POPs. We observed an increased chance for incident diabetes for PCB-138 and PCB-153 with an odds ratio (OR) of 1.50 (95%CI: 1.07-2.11) and 1.53 (1.15-2.04) per interquartile range increase in the respective POP. In addition, explorative results suggested higher OR for women and non-obese participants.

CONCLUSIONS:

Our results add to the evidence on diabetogenic effects of POPs in the general population, and warrant both policies to prevent human exposure to POPs and additional research on the adverse effects of more complex chemical mixtures.

KEYWORDS:

Case-control study; Environmental contaminates; Epidemiology; Incidence; Type 2 diabetes

PMID:
31132656
DOI:
10.1016/j.envint.2019.05.030
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