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Nutrients. 2019 May 25;11(5). pii: E1171. doi: 10.3390/nu11051171.

Dietary Flaxseed as a Strategy for Improving Human Health.

Parikh M1,2,3, Maddaford TG4,5,6, Austria JA7,8,9, Aliani M10,11, Netticadan T12,13,14, Pierce GN15,16,17.

Author information

1
Department of Physiology and Pathophysiology, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0W3, Canada. mparikh@sbrc.ca.
2
Canadian Centre for Agri-Food Research in Health and Medicine (CCARM), Albrechtsen Research Centre, St Boniface Hospital, 351 Taché Avenue, Winnipeg, MB R2H 2A6, Canada. mparikh@sbrc.ca.
3
Institute of Cardiovascular Sciences, Albrechtsen Research Centre, St. Boniface Hospital, 351 Taché Avenue, Winnipeg, MB R2H 2A6, Canada. mparikh@sbrc.ca.
4
Department of Physiology and Pathophysiology, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0W3, Canada. tmaddaford@sbrc.ca.
5
Canadian Centre for Agri-Food Research in Health and Medicine (CCARM), Albrechtsen Research Centre, St Boniface Hospital, 351 Taché Avenue, Winnipeg, MB R2H 2A6, Canada. tmaddaford@sbrc.ca.
6
Institute of Cardiovascular Sciences, Albrechtsen Research Centre, St. Boniface Hospital, 351 Taché Avenue, Winnipeg, MB R2H 2A6, Canada. tmaddaford@sbrc.ca.
7
Department of Physiology and Pathophysiology, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0W3, Canada. aaustria@sbrc.ca.
8
Canadian Centre for Agri-Food Research in Health and Medicine (CCARM), Albrechtsen Research Centre, St Boniface Hospital, 351 Taché Avenue, Winnipeg, MB R2H 2A6, Canada. aaustria@sbrc.ca.
9
Institute of Cardiovascular Sciences, Albrechtsen Research Centre, St. Boniface Hospital, 351 Taché Avenue, Winnipeg, MB R2H 2A6, Canada. aaustria@sbrc.ca.
10
Canadian Centre for Agri-Food Research in Health and Medicine (CCARM), Albrechtsen Research Centre, St Boniface Hospital, 351 Taché Avenue, Winnipeg, MB R2H 2A6, Canada. maliani@sbrc.ca.
11
Department of Human Nutritional Sciences, Faculty of Agricultural and Food Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada. maliani@sbrc.ca.
12
Department of Physiology and Pathophysiology, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0W3, Canada. tnetticadan@sbrc.ca.
13
Canadian Centre for Agri-Food Research in Health and Medicine (CCARM), Albrechtsen Research Centre, St Boniface Hospital, 351 Taché Avenue, Winnipeg, MB R2H 2A6, Canada. tnetticadan@sbrc.ca.
14
Morden Research and Development Centre, Agriculture and Agri-Food Canada, Morden, MB R6M 1Y5, Canada. tnetticadan@sbrc.ca.
15
Department of Physiology and Pathophysiology, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0W3, Canada. gpierce@sbrc.ca.
16
Canadian Centre for Agri-Food Research in Health and Medicine (CCARM), Albrechtsen Research Centre, St Boniface Hospital, 351 Taché Avenue, Winnipeg, MB R2H 2A6, Canada. gpierce@sbrc.ca.
17
Institute of Cardiovascular Sciences, Albrechtsen Research Centre, St. Boniface Hospital, 351 Taché Avenue, Winnipeg, MB R2H 2A6, Canada. gpierce@sbrc.ca.

Abstract

Flaxseed is a rich source of the omega-3 fatty acid, alpha linolenic acid, the lignan secoisolariciresinol diglucoside and fiber. These compounds provide bioactivity of value to the health of animals and humans through their anti-inflammatory action, anti-oxidative capacity and lipid modulating properties. The characteristics of ingesting flaxseed or its bioactive components are discussed in this article. The benefits of administering flaxseed or the individual bioactive components on health and disease are also discussed in this review. Specifically, the current evidence on the benefits or limitations of dietary flaxseed in a variety of cardiovascular diseases, cancer, gastro-intestinal health and brain development and function, as well as hormonal status in menopausal women, are comprehensive topics for discussion.

KEYWORDS:

cancer; cardiovascular; diabetes; flaxseed; functional food; menopause; microbiome; nutraceutical

PMID:
31130604
PMCID:
PMC6567199
DOI:
10.3390/nu11051171
[Indexed for MEDLINE]
Free PMC Article

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