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J Allergy Clin Immunol Pract. 2019 May 24. pii: S2213-2198(19)30472-6. doi: 10.1016/j.jaip.2019.05.017. [Epub ahead of print]

Quality of Life in Patients with Allergic Reactions to Medications: Influence of a Drug Allergy Evaluation.

Author information

1
Department of Allergy, Clínica Universidad de Navarra, Pamplona, Spain; RETIC de Asma, Reacciones adversas y Alérgicas (ARADYAL), Madrid, Spain. Electronic address: gastaminza@unav.es.
2
Department of Preventive Medicine and Public Health, University of Navarra, IdisNA, Pamplona, Spain; CIBER de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
3
Allergology Service, Hospital Universitari de Bellvitge-IDIBELL, L'Hospitalet de Llobregat, Spain.
4
Allergology Service, Reina Sofía University Hospital, Córdoba, Spain.
5
Department of Allergy, Hospital La Paz Health Research Institute (IdiPAZ), Madrid, Spain.
6
Department of Allergology and Pneumology, Hospital Quironsalud Campo de Gibraltar, Cadiz, Spain.
7
Department of Allergy, Clínica Universidad de Navarra, Pamplona, Spain; RETIC de Asma, Reacciones adversas y Alérgicas (ARADYAL), Madrid, Spain.
8
Allergy Unit, Allergo-Anaesthesia Unit, Hospital Central de la Cruz Roja, Madrid, Spain; Faculty of Medicine, Alfonso X El Sabio University, Villanueva de la Cañada, Spain; RETIC de Asma, Reacciones adversas y Alérgicas (ARADYAL), Madrid, Spain.
9
Department of Allergy, San Pedro University Hospital, Logroño (La Rioja), Spain.
10
Department of Allergy, Puerta de Hierro University Hospital, Madrid, Spain.
11
Allergology Unit, Hospital Universitario Lucus Augusti, Lugo, Spain.
12
Department of Allergy, 12 de Octubre University Hospital, Madrid, Spain.
13
Department of Allergy, University Hospital of Salamanca, Salamanca, Spain; RETIC de Asma, Reacciones adversas y Alérgicas (ARADYAL), Madrid, Spain.
14
Allergy Section, Torrecárdenas University Hospital, Almería, Spain.
15
Allergy Service, University Hospital Dr Negrín of Gran Canaria, Las Palmas de Gran Canaria, Spain.
16
Department of Allergy, Gregorio Marañón General University Hospital, Madrid, Spain.
17
Allergy Unit, Alcorcón Foundation University Hospital, Madrid, Spain.
18
Allergy Unit, IBIMA-Regional Universitary Hospital of Málaga, Málaga, Spain; RETIC de Asma, Reacciones adversas y Alérgicas (ARADYAL), Madrid, Spain.
19
Allergology Service, San Carlos Clinical Hospital, Madrid, Spain; RETIC de Asma, Reacciones adversas y Alérgicas (ARADYAL), Madrid, Spain.
20
Department of Allergy, Severo Ochoa University Hospital, Leganes, Spain.

Abstract

BACKGROUND:

Suspicion of allergic drug reaction can cause important disturbances in the patient's life.

OBJECTIVE:

We evaluated in a prospective multicenter study the quality of life of patients who suffered a possible allergic drug reaction, and analyzed the effect of a drug allergy evaluation.

METHODS:

Patients (>18 years old) answered the specific questionnaire twice: before the drug allergy evaluation, and 1 month after it was completed. Statistics were performed using STATA.

RESULTS:

A total of 360 patients (240, 66.6% female; mean age, 45.4 years; standard deviation [SD], 15.6 years) completed the first questionnaire. After the evaluation, 150 of 346 patients (43.4%) were diagnosed as allergic to the drug (115 of 150 immediate; 35 of 150 delayed) and 196 of 346 patients (56.6%) as nonallergic. The mean value of the first questionnaire was 32.14 (SD, 11.84); patients with anaphylaxis, nonanaphylactic immediate reaction, with more than 1 drug reaction, or a chronic osteoarticular disease, had a statistically significant higher score in Q0 (worse quality of life). After the allergy study, the mean of the second questionnaire was 27.27 (SD, 9.96), showing a global improvement (P < .001). No statistically significant difference was found between drug allergic and non-drug allergic patients (P = .340); however, being >40 years old (P = .030), having a chronic osteoarticular disease (P = .003) and having more than 1 reaction to drugs (P < .001) were associated with a statistically significant worse quality of life after the evaluation.

CONCLUSIONS:

Having suffered anaphylaxis, more than 1 reported drug allergy or presenting a musculoskeletal disease are factors that worsen the quality of life. Quality of life improved significantly after completing a drug allergy evaluation.

KEYWORDS:

Anaphylaxis; Diagnosis; Drug allergy; Health-related quality of life; Well-being

PMID:
31129076
DOI:
10.1016/j.jaip.2019.05.017

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