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Psychooncology. 2019 May 25. doi: 10.1002/pon.5126. [Epub ahead of print]

A Randomized Control Trial of Stress Management for Caregivers of Stem Cell Transplant Patients: Effect on Patient Quality of Life and Caregiver Distress.

Author information

1
University of Colorado Anschutz Medical Campus, Aurora.
2
University of Colorado Denver, Denver.
3
Colorado Blood Cancer Institute, Denver.

Abstract

BACKGROUND:

Psychological interventions reduce caregiver distress. Less distress in caregivers may contribute to improved patient quality of life (QoL) but empirical evidence is lacking. Will a caregiver stress management intervention improve patient QoL?

METHODS:

In this replication study, we randomized 155 allogeneic hematopoietic stem cell transplant (Allo-HSCT) patients and caregivers to PsychoEducation, Paced Respiration, and Relaxation (PEPRR) or enhanced treatment as usual (eTAU). We provided PEPRR over three months following transplant. Functional Assessment of Cancer Therapy - BMT (FACT-BMT) evaluated patient QoL and caregiver distress (CG-distress) was based on depressive, anxious, and stress symptoms. Hierarchical linear models tested intervention, time, and interactions as fixed effects with participant as random effects.

RESULTS:

Patients whose caregivers received PEPPR did not differ on FACT-BMT between baseline and 6 months (Mean=+3.74, 95% CI=-3.54, 11.02) compared to patients of caregivers in eTAU (Mean=+3.16, 95% CI=-2.88, 9.20) even though CG-Distress was decreased by PEPPR (Mean=-0.23, 95% CI=-0.448, -0.010) compared to those receiving eTAU (Mean=+0.27, 95% CI=0.033, 0.504) at 6 mo.

CONCLUSIONS:

PEPRR reduced caregiver distress without affecting their patient's FACT-BMT score. The FACT-BMT may not have distinguished unique psychological changes associated with their caregiver receiving PEPRR.

KEYWORDS:

and stress; anxiety; cancer; caregiver; depression; oncology; quality of life; stem cell transplant; stress management

PMID:
31127974
DOI:
10.1002/pon.5126

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