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APMIS. 2019 Aug;127(8):554-560. doi: 10.1111/apm.12970.

PD-L1 expression and deficient mismatch repair in ductal adenocarcinoma of the prostate.

Author information

1
Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
2
Department of Pathology and Molecular Medicine, Wellington School of Medicine and Health Sciences, University of Otago, Wellington, New Zealand.
3
Aquesta Uropathology and University of Queensland, Brisbane, Queensland, Australia.
4
Wesley Urology Clinic, Brisbane, Queensland, Australia.
5
Department of Molecular Medicine and Surgery (MMK), Karolinska Institutet, Stockholm, Sweden.
6
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Abstract

This study aimed to investigate the expression of programmed death receptor ligand 1 (PD-L1) and deficient mismatch repair (dMMR) in ductal adenocarcinoma of the prostate. A tissue microarray of 32 ductal and 42 grade-matched acinar adenocarcinomas was used. Slides were stained for PD-L1, PD-L2, MMR proteins, CD4 and CD8. PD-L1 expression in tumor cells was only seen in 3% (1/34) of ductal and 5% (2/42) of acinar adenocarcinomas (p = 1.0), while PD-L1 expression in tumor-infiltrating immune cells was seen in 29% (10/34) of ductal and 14% (6/42) of acinar adenocarcinomas (p = 0.16). dMMR, as defined by loss of one or more of the MMR proteins, was identified in 5% (4/73) of cases, including 1 ductal and 3 acinar adenocarcinomas. There was a suggested association between infiltration of CD8+ lymphocytes and ductal subtype (p = 0.04) but not between CD4+ lymphocytes and tumor type (p = 0.28). The study shows that both dMMR and PD-L1 expression is uncommon in tumor cells of both ductal and acinar adenocarcinoma of the prostate, while PD-L1 expression in tumor-infiltrating immune cells is a more common finding.

KEYWORDS:

Ductal adenocarcinoma; PD-L1; microsatellite instability; prostate; tumor-infiltrating lymphocytes

PMID:
31127651
DOI:
10.1111/apm.12970
[Indexed for MEDLINE]

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