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Clin Exp Immunol. 2019 Sep;197(3):294-307. doi: 10.1111/cei.13334. Epub 2019 Jun 9.

The immune system and psychiatric disease: a basic science perspective.

Author information

1
Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
2
Department of Psychiatry and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.

Abstract

Mental illness exerts a major burden on human health, yet evidence-based treatments are rudimentary due to a limited understanding of the underlying pathologies. Clinical studies point to roles for the immune system in psychiatric diseases, while basic science has revealed that the brain has an active and multi-cellular resident immune system that interacts with peripheral immunity and impacts behavior. In this perspective, we highlight evidence of immune involvement in human psychiatric disease and review data from animal models that link immune signaling to neuronal function and behavior. We propose a conceptual framework for linking advances in basic neuroimmunology to their potential relevance for psychiatric diseases, based on the subtypes of immune responses defined in peripheral tissues. Our goal is to identify novel areas of focus for future basic and translational studies that may reveal the potential of the immune system for diagnosing and treating mental illnesses.

KEYWORDS:

brain; human; neuroimmunology; psychiatry

PMID:
31125426
PMCID:
PMC6693968
[Available on 2020-09-01]
DOI:
10.1111/cei.13334

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