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Clin Transplant. 2019 May 23:e13611. doi: 10.1111/ctr.13611. [Epub ahead of print]

Methicillin-resistant Staphylococcus aureus in Solid Organ Transplantation - Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.

Author information

1
Columbia University Medical Center, Medicine, 622 W 168 th st, Box 82, New York, United States.
2
Icahn School of Medicine at Mount Sinai, Medicine, New York, United States.

Abstract

These updated guidelines from the American Society of Transplantation Infectious Diseases Community of Practice review the epidemiology, diagnosis, prevention and management of methicillin-resistant Staphylococcus aureus (MRSA) infections in solid organ transplantation. Despite an increasing armamentarium of antimicrobials active against MRSA, improved diagnostic tools, and overall declining rates of infection, MRSA infections remain a substantial cause of morbidity and mortality in solid organ transplant recipients. Pre- and post-transplant MRSA colonization is a significant risk factor for post-transplant MRSA infection. The preferred initial treatment of MRSA bacteremia remains vancomycin. Hand hygiene, chlorhexidine bathing in the ICU, central line bundles that focus on reducing unnecessary catheter use, disinfection of patient equipment and the environment along with antimicrobial stewardship are all aspects of an infection prevention approach to prevent MRSA transmission and decrease healthcare-associated infections. This article is protected by copyright. All rights reserved.

KEYWORDS:

Methicillin-resistant Staphylococcus aureus; bacteremia; pneumonia; prevention; solid organ transplantation; treatment

PMID:
31120612
DOI:
10.1111/ctr.13611

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