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Chem Commun (Camb). 2019 Jun 6;55(47):6735-6738. doi: 10.1039/c9cc02901j.

A NIR-triggered gatekeeper of supramolecular conjugated unimicelles with two-photon absorption for controlled drug release.

Author information

1
School of Chemistry and Chemical Engineering, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, Shanghai Jiao Tong University, 800 Dong Chuan Road, Shanghai 200240, P. R. China. xyzhu@sjtu.edu.cn.

Abstract

A near-infrared (NIR)-sensitive gated assembly of supramolecular conjugated unimicelles based on robust host-guest recognition between a β-cyclodextrin-grafted hyperbranched conjugated polymer and azobenzene-functionalized poly(ethylene glycol) was constructed. Utilized as a drug carrier, these unimicelles exhibited controlled drug release through the NIR-triggered photoisomerization of azobenzene in cancer cells via a two-photon excited fluorescence resonance energy transfer (TP-FRET) approach, leading to efficient cancer therapy.

PMID:
31119236
DOI:
10.1039/c9cc02901j
[Indexed for MEDLINE]

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