Ocular surface squamous neoplasia: angiographic characteristics and response to subconjunctival/perilesional 5-fluorouracil injections

Drug Des Devel Ther. 2019 Apr 29:13:1323-1334. doi: 10.2147/DDDT.S191161. eCollection 2019.

Abstract

Introduction: To investigate the angiographic characteristics of ocular surface squamous neoplasia (OSSN) and to evaluate the efficacy of subconjunctival/perilesional 5-fluorouracil injections in OSSN cases. Materials and methods: Six eyes of six patients with primary OSSN, received perilesional, subconjunctival, 25-mg/mL 5-fluorouracil injections at certain intervals. Anterior segment digital photography images, anterior segment optical coherence tomography (AS-OCT), and conjunctival indocyanine green angiography (ICGA) were obtained simultaneously with fluorescein angiography. Results: The mean best-corrected vision acuity significantly improved after treatment. At baseline, the median of the largest thickness of OSSN was 905.0 (interquartile range: 492.0-1592.5) μm based on AS-OCT data. There was an abrupt transition between normal and abnormal epithelium, a thickened hyper-reflective epithelium, and a sharp plane of cleavage between the lesion and underlying tissue, all indicative of OSSN. The angiographic characteristics of OSSN included focal or seafan-shaped intratumoral and conjunctival feeding vessels visible via ICGA, and abnormal vascular leakage visible with fluorescein angiography. The median time to tumor regression after treatment was 35.0 (interquartile range: 32.0-45.5) days in five eyes without recurrence, and OSSN in one eye regressed partially 40 days after treatment. Conclusion: This is the first report of the angiographic characteristics of OSSN and its response to subconjunctival/perilesional 5-fluorouracil injections by simultaneous conjunctival angiography and AS-OCT. The improved subconjunctival/perilesional 5-fluorouracil injection was an effective therapy for OSSN in both best-corrected vision acuity gain and anatomic outcomes.

Keywords: anterior segment optical coherence tomography; conjunctival angiography; ocular surface squamous neoplasia; subconjunctival 5-flourouracil injection.

MeSH terms

  • Aged
  • Antimetabolites, Antineoplastic / administration & dosage*
  • Antimetabolites, Antineoplastic / therapeutic use*
  • Carcinoma, Squamous Cell / diagnostic imaging
  • Carcinoma, Squamous Cell / drug therapy*
  • Eye Neoplasms / diagnostic imaging
  • Eye Neoplasms / drug therapy*
  • Female
  • Fluorescein Angiography*
  • Fluorouracil / administration & dosage*
  • Fluorouracil / therapeutic use*
  • Humans
  • Indocyanine Green / chemistry
  • Injections, Intraocular
  • Male
  • Middle Aged
  • Retrospective Studies

Substances

  • Antimetabolites, Antineoplastic
  • Indocyanine Green
  • Fluorouracil