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Insights Imaging. 2019 May 21;10(1):56. doi: 10.1186/s13244-019-0733-7.

An update on Burkitt lymphoma: a review of pathogenesis and multimodality imaging assessment of disease presentation, treatment response, and recurrence.

Author information

1
Department of Radiology, Duke University, Durham, NC, USA.
2
Department of Imaging, Dana Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA. falessandrino@bwh.harvard.edu.
3
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. falessandrino@bwh.harvard.edu.
4
Department of Pathology, UH Cleveland Medical Center, Case Western Reserve University, Cleveland, OH, USA.
5
Department of Radiology, UH Cleveland Medical Center, Case Western Reserve University, Cleveland, OH, USA.
6
Department of Imaging, Dana Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA.
7
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Abstract

Burkitt lymphoma (BL) is a highly aggressive, rapidly growing B cell non-Hodgkin lymphoma, which manifests in several subtypes including sporadic, endemic, and immunodeficiency-associated forms. Pathologically, BL is classically characterized by translocations of chromosomes 8 and 14 resulting in upregulation of the c-myc protein transcription factor with upregulation of cell proliferation. BL affects nearly every organ system, most commonly the abdomen and pelvis in the sporadic form. Imaging using a multimodality approach plays a crucial role in the management of BL from diagnosis, staging, and evaluation of treatment response to therapy-related complications with ultrasound, computed tomography, magnetic resonance imaging, and positron emission tomography playing roles. In this article, we review the pathobiology and classification of BL, illustrate a multimodality imaging approach in evaluating common and uncommon sites of involvement within the trunk and head and neck, and review common therapies and treatment-related complications.

KEYWORDS:

B cell; Burkitt lymphoma; Computed tomography; Diagnostic imaging; Drug therapy; Lymphoma

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