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Eur J Nutr. 2019 May 21. doi: 10.1007/s00394-019-02000-w. [Epub ahead of print]

Dietary patterns associated with inflammatory biomarkers in a Northern German population.

Author information

1
Department of Nutrition and Food Sciences, Nutritional Epidemiology, University of Bonn, Bonn, Germany. janett.barbaresko@ddz.de.
2
Institute for Biometry and Epidemiology, German Diabetes Center, Leibniz Institute for Diabetes Research at the Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany. janett.barbaresko@ddz.de.
3
Department of Nutrition and Food Sciences, Nutritional Epidemiology, University of Bonn, Bonn, Germany.
4
LifeLines Cohort Study, Groningen, The Netherlands.
5
PopGen Biobank, University Hospital Schleswig-Holstein, Kiel, Germany.
6
Institute of Epidemiology, Christian Albrecht University, University Hospital Schleswig-Holstein, Kiel, Germany.
7
Department of General Internal Medicine, University Hospital Schleswig-Holstein, Kiel, Germany.

Abstract

PURPOSE:

The aim of the present study was to derive overall and sex-specific dietary patterns associated with inflammatory biomarkers in a general population sample from Northern Germany.

METHODS:

The present analysis included 1158 participants (477 men, 681 women, mean age: 53.1 years; mean body mass index: 26.2 kg/m2) of the Food Chain Plus (FoCus) cohort in Kiel, Germany. Participants completed a semi-quantitative food frequency questionnaire and provided blood samples. Reduced rank regression with C-reactive protein (CRP) and Interleukin 6 (IL-6) as response variables was used to derive dietary patterns. After a mean follow-up of 1.7 years, a second blood sample was obtained in a subsample of 112 individuals. Multiple regression models were used to examine the association between dietary patterns at baseline and inflammatory biomarkers at follow-up.

RESULTS:

The overall pattern characterised by high intakes of soft drinks, meat, potatoes and sauce, and low intakes of other cereals (except pasta/rice), wine, nuts, seeds, vegetarian dishes, vegetable oil, and fish was positively associated with CRP (OR 2.20; 95% CI 1.12, 4.35) and IL-6 (OR 3.14; 95% CI 1.26, 7.87) at follow-up. In men, the dietary pattern was higher in soft drinks, processed meat and low in cereals and plant-based fats. In women, the pattern was characterised by soft drinks, meat, vegetables and low in other cereals, wine, nuts, and seeds. The association between sex-specific patterns with inflammatory biomarkers was weaker for CRP.

CONCLUSION:

We identified dietary patterns positively associated with established biomarkers of chronic low-grade inflammation.

KEYWORDS:

Dietary pattern analysis; Low-grade inflammation; Reduced rank regression

PMID:
31115681
DOI:
10.1007/s00394-019-02000-w

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