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Endosc Ultrasound. 2019 May 9. doi: 10.4103/eus.eus_12_19. [Epub ahead of print]

The difference in histological yield between 19G EUS-FNA and EUS-fine-needle biopsy needles.

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Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore.
Department of Laboratory Medicine, Changi General Hospital, Singapore.


Background and Objective:

EUS-guided fine-needle biopsy (EUS-FNB) with acquisition of tissue core is possible with the use of 19G fine-needle aspiration (FNA) and dedicated biopsy needles. Published data of direct comparisons between biopsy needles are more limited compared to the abundant data comparing EUS-FNA with EUS-FNB. We performed a retrospective study to determine the difference in histologic yield between 19G FNA needle and EUS-FNB needles in patients with solid masses.

Materials and Methods:

Consecutive patients who underwent EUS-FNB of solid masses from January 2014 to July 2018 were identified from a database. The difference in histologic yield between needles was analyzed.


A total of 159 patients underwent 179 EUS-FNB procedures (median of 2 needle passes [range: 1-4]). The use of 19G FNA, 19G, 20G, and 22G FNB needles allowed acquisition of a histologic core in 67.4% (29/43), 72.5% (29/40), 82.1% (46/56), and 75.9% (22/29), respectively (P = 0.368). A significant difference in the yield of histologic core was detected when 19G FNA needle was compared with 22G Acquireâ„¢ FNB needle (67.4% [29/43] vs. 94.1% [16/17], P = 0.032). The presence of histologic core was significantly associated with a positive diagnosis (95.6% vs. 30.2%, P < 0.0001).


EUS-FNB with acquisition of histologic core improved the diagnostic yield. Dedicated FNB needles appeared to achieve a higher yield of histologic core compared to 19G FNA needles.


Aspiration; biopsy; cytology; endoscopic ultrasound; histology; needles

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