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Med Sci (Paris). 2019 May;35(5):463-466. doi: 10.1051/medsci/2019079. Epub 2019 May 22.

[The oyster Crassostrea gigas, a new model against cancer].

[Article in French]

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Équipe soutenue par la fondation ARC, Ifremer, UMR 6539 CNRS-UBO-IRD-Ifremer, Laboratoire des sciences de l'environnement marin, 29280 Plouzané, France.
Inserm U1180, Université Paris Sud, 5, rue JB Clément, 92296 Châtenay-Malabry, France.
Inserm U1065, Centre méditerranéen de médecine moléculaire, 151, route St Antoine de Ginestière, 06204 Nice, France.


The Warburg effect is one of the hallmarks of cancer cells in humans. It is a true metabolic reprogramming to aerobic glycolysis, allowing cancer cells to meet their particular energy needs for growth, proliferation, and resistance to apoptosis, depending on the microenvironment they encounter within the tumor. We have recently discovered that the Crassostrea gigas oyster can naturally reprogram its metabolism to the Warburg effect. Thus, the oyster becomes a new invertebrate model useful for cancer research. Due to its lifestyle, the oyster C. gigas has special abilities to adapt its metabolism to the extreme changes in the environment in which it is located. The oyster C. gigas is therefore a model of interest to study how the environment can control the Warburg effect under conditions that could not be explored in vertebrate model species.


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