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Microb Cell. 2019 Apr 24;6(5):217-256. doi: 10.15698/mic2019.05.677.

Ser/Thr protein phosphatases in fungi: structure, regulation and function.

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1
Departament de Bioquímica i Biologia Molecular and Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Barcelona, Spain.

Abstract

Reversible phospho-dephosphorylation of proteins is a major mechanism for the control of cellular functions. By large, Ser and Thr are the most frequently residues phosphorylated in eukar-yotes. Removal of phosphate from these amino acids is catalyzed by a large family of well-conserved enzymes, collectively called Ser/Thr protein phosphatases. The activity of these enzymes has an enormous impact on cellular functioning. In this work we pre-sent the members of this family in S. cerevisiae and other fungal species, and review the most recent findings concerning their regu-lation and the roles they play in the most diverse aspects of cell biology.

KEYWORDS:

S. cerevisiae; cell signaling; fungi; protein phosphatases; protein phosphorylation

Conflict of interest statement

Conflict of interest: The authors declare no conflict of interest.

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