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Future Sci OA. 2019 Feb 21;5(4):FSO377. doi: 10.4155/fsoa-2018-0109. eCollection 2019 Apr.

Pilot study on patients with Mal de Debarquement syndrome during pregnancy.

Mucci V1,2,3,4,1,2,3,4, Canceri JM5,5, Jacquemyn Y6,6, Ombergen AV1,2,1,2, Maes LK7,7, Van de Heyning PH1,2,1,2, Browne CJ5,8,5,8.

Author information

Translational Neurosciences, Faculty of Medicine & Health Sciences, University of Antwerp, Antwerp University Hospital, Wilrijkstraat 10 (Route 71-125), 2650 Edegem, Antwerp, Belgium.
Department of Otorhinolaryngology & Head & Neck Surgery, Antwerp University Hospital, Wilrijkstraat 10 (Route 71-125), 2650 Edegem, Antwerp, Belgium.
Swiss Concussion Center, Schulthess Klinik, Lengghalde 2, CH-8008 Zürich, Switzerland.
Department of Neurology, Zurich University, University Hospital Zurich, Frauenklinkstrasse 26, 8091, Zürich, Switzerland.
School of Science & Health, Western Sydney University, Room 21.1.12, Campbelltown Campus, NSW 2560, Australia.
Department of Gynaecology, Antwerp University Hospital, University of Antwerp, Wilrijkstraat 10 (route 71-125), 2650 Edegem, Antwerp, Belgium.
Ghent University, Department of Audiology, Faculty of Medicine & Health Science, University Hospital Ghent, Ghent University, Ghent, Belgium.
Translational Neuroscience Facility, School of Medical Sciences, Room 316, Level 3, Wallace Wurth Building, UNSW Sydney, NSW 2052, Australia.



To evaluate if patients with Mal de Debarquement syndrome (MdDS) demonstrate different symptom levels or symptom type during pregnancy.

Materials & methods:

18 MdDS patients that were or had been pregnant during their condition were recruited to complete a retrospective online questionnaire. Respondents answered questions regarding their basic clinical data, diagnosis, triggers and differences in symptom level and symptom type during pregnancy and before pregnancy.


A total of 81.3% reported that their symptoms were reduced during pregnancy compared with before pregnancy. Respondents also reported a different perception of motion and experienced less dizziness while being pregnant.


The physiological changes that occur during pregnancy improve the symptoms of patients with MdDS, and this is potentially attributable to the rise in estrogen and progesterone.


Mal de Debarquement syndrome (MdDS); MdDS symptoms; estrogen; pregnancy

Conflict of interest statement

Financial & competing interests disclosure This publication was supported by the Future Science Early Research Career Award awarded to V Mucci. This work was supported by a Western Sydney University Research Initiatives Early Career Researchers Grant awarded to CJ Browne. V Mucci and A Van Ombergen were funded by the PRODEX programme of the Belgian Science Policy during the time the study was developed and performed. The authors have no other relevant affiliations or financial involvement with any organisation or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilised in the production of this manuscript.

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