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Curr Opin Genet Dev. 2019 Apr;55:46-51. doi: 10.1016/j.gde.2019.04.014. Epub 2019 May 18.

Epigenetic gene regulation, chromatin structure, and force-induced chromatin remodelling in epidermal development and homeostasis.

Author information

1
Helsinki Institute of Life Science, University of Helsinki, Biomedicum Helsinki, Haartmaninkatu 8, 00290, Finland; Wihuri Research Institute, University of Helsinki, Finland; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Finland; Max Planck Institute for Biology of Ageing, Cologne, Germany.
2
Black Family Stem Cell Institute, Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.
3
Black Family Stem Cell Institute, Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA. Electronic address: elena.ezhkova@mssm.edu.
4
Helsinki Institute of Life Science, University of Helsinki, Biomedicum Helsinki, Haartmaninkatu 8, 00290, Finland; Wihuri Research Institute, University of Helsinki, Finland; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Finland; Max Planck Institute for Biology of Ageing, Cologne, Germany. Electronic address: sara.wickstrom@helsinki.fi.

Abstract

The skin epidermis is a constantly renewing stratified epithelium that provides essential protective barrier functions throughout life. Epidermal stratification is governed by a step-wise differentiation program that requires precise spatiotemporal control of gene expression. How epidermal self-renewal and differentiation are regulated remains a fundamental open question. Cell-intrinsic and cell-extrinsic mechanisms that modify chromatin structure and interactions have been identified as key regulators of epidermal differentiation and stratification. Here, we will review the recent advances in our understanding of how chromatin modifiers, tissue-specific transcription factors, and force-induced nuclear remodeling processes function to shape chromatin and to control epidermal tissue development and homeostasis.

PMID:
31112907
DOI:
10.1016/j.gde.2019.04.014
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