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Histopathology. 2019 May 20. doi: 10.1111/his.13924. [Epub ahead of print]

Correlation of molecular and morphologic features of appendiceal epithelial neoplasms.

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Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan.
Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan.
Graduate Institute of Pathology, College of Medicine, National Taiwan University, Taiwan.



The aims of this study were to identify the genetic features of appendiceal epithelial neoplasm and correlate the genetic features and morphology.


We analyzed the genetic features of a series of 47 appendiceal epithelial neoplasms of various morphologies by using targeted next-generation sequencing of 11 genes commonly mutated in gastrointestinal neoplasms. Seven of nine serrated polyps harbored BRAF mutations, which are rare in other types of tumors. Most cases of low-grade appendiceal mucinous neoplasms (LAMNs) exhibited GNAS and KRAS mutations. LAMNs with a coexisting serrated polyp were all KRAS mutated. Four LAMNs with mutations in the Wnt/β-catenin pathway, either through inactivating mutations in APC or RNF43 or through activating mutations in CTNNB1, had focal proliferation of mucin-poor low-grade tumor cells, reminiscent of colorectal adenomas. Mutations in the Wnt/β-catenin pathway were also identified in high-grade appendiceal mucinous neoplasms, suggesting that Wnt/β-catenin pathway activation is the driving force for the progression of a LAMN to a higher grade lesion. Adenomatous polyps frequently had APC, KRAS, and TP53 mutations and were morphologically and molecularly similar to adenomatous polyps of the colorectum.


Our results indicate a close association between morphology and genetic events in appendiceal neoplasms and suggest a phylogenetic relationship between different entities. This article is protected by copyright. All rights reserved.


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