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J Oral Maxillofac Pathol. 2019 Jan-Apr;23(1):140-143. doi: 10.4103/jomfp.JOMFP_78_17.

Clear cell odontogenic carcinoma: Case report of a deceptive pathology.

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Department of Oral Pathology and Microbiology, Government Dental College and Hospital, Aurangabad, Maharashtra, India.
Department of Dentistry, S.R.T.R. Government Medical College, Ambajogai, Maharashtra, India.


Clear cells are associated with numerous physiological and pathological conditions. Odontogenic cysts and tumors can arise from physiological clear cells like rests of dental lamina. One such clear cell neoplasm is clear cell odontogenic carcinoma (CCOC) that is associated with aggressive clinical behavior, metastasis and low survival rate. With <80 cases reported so far, it is a rare entity. Initially described as a clear cell odontogenic tumor considering it as a benign but invasive neoplasm, it was later termed as CCOC owing to its infiltrative nature with a marked tendency for local recurrence, regional nodal spread and possible distant, mainly pulmonary, metastasis. Reported here is a case of CCOC affecting mandible of a 55-year-old female along with its immunohistochemical workup.


Clear cell lesions; clear cell odontogenic carcinoma; pathogenesis; treatment

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