Format

Send to

Choose Destination
Antimicrob Agents Chemother. 2019 Jul 25;63(8). pii: e00380-19. doi: 10.1128/AAC.00380-19. Print 2019 Aug.

The bla NDM-1-Carrying IncA/C2 Plasmid Underlies Structural Alterations and Cointegrate Formation In Vivo.

Author information

1
Department for Biological Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany.
2
European Food Safety Authority, Parma, Italy.
3
Departamento de Sanidad Animal and Centro de Vigilancia Sanitaria Veterinaria, Facultad de Veterinaria, Universidad Complutense de Madrid, Madrid, Spain.
4
Department for Biological Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany istvan.szabo@bfr.bund.de.

Abstract

In 2012, a carbapenemase-producing Salmonella enterica serovar Corvallis isolate carrying a bla NDM-1 multiresistance IncA/C2 plasmid, apart from IncHI2 and ColE-like plasmids, was detected in a wild bird in Germany. In a recent broiler chicken infection study, we observed transfer of this bla NDM-1-carrying IncA/C2 plasmid to other Enterobacteriaceae Here, we focused on the stability of this plasmid and gained insight into the type and frequency of its structural alterations after an in vivo passage in a broiler chicken infection study.

KEYWORDS:

NDM-1 carbapenemases; Salmonella ; broiler chicken infection study

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center