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Molecules. 2019 May 19;24(10). pii: E1926. doi: 10.3390/molecules24101926.

Neuroprotective and Anti-Amyloid β Effect and Main Chemical Profiles of White Tea: Comparison Against Green, Oolong and Black Tea.

Li X1,2,3, Smid SD4, Lin J5,6, Gong Z7, Chen S8,9, You F10, Zhang Y11, Hao Z12,13, Lin H14, Yu X15, Jin X16.

Author information

1
College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou 350002, China. lxlfafu@163.com.
2
FAFU-UCR Joint Center for Horticultural Biology and Metabolomics, Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology, Fujian Agriculture and Forestry University, Fuzhou 350002, China. lxlfafu@163.com.
3
Discipline of Pharmacology, School of Medical Sciences, Faculty of Health Sciences, The University of Adelaide, South Australia 5000, Australia. lxlfafu@163.com.
4
Discipline of Pharmacology, School of Medical Sciences, Faculty of Health Sciences, The University of Adelaide, South Australia 5000, Australia. scott.smid@adelaide.edu.au.
5
FAFU-UCR Joint Center for Horticultural Biology and Metabolomics, Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology, Fujian Agriculture and Forestry University, Fuzhou 350002, China. realnadal@163.com.
6
Fujian Institute of Microbiology, Fuzhou 350007, China. realnadal@163.com.
7
FAFU-UCR Joint Center for Horticultural Biology and Metabolomics, Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology, Fujian Agriculture and Forestry University, Fuzhou 350002, China. zhihong_gong@sina.com.
8
College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou 350002, China. cstc1990@hotmail.com.
9
FAFU-UCR Joint Center for Horticultural Biology and Metabolomics, Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology, Fujian Agriculture and Forestry University, Fuzhou 350002, China. cstc1990@hotmail.com.
10
College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou 350002, China. youfangning123@163.com.
11
College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou 350002, China. zy9531615@163.com.
12
College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou 350002, China. haozhilong@126.com.
13
FAFU-UCR Joint Center for Horticultural Biology and Metabolomics, Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology, Fujian Agriculture and Forestry University, Fuzhou 350002, China. haozhilong@126.com.
14
College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou 350002, China. linhongzheng2010@126.com.
15
FAFU-UCR Joint Center for Horticultural Biology and Metabolomics, Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology, Fujian Agriculture and Forestry University, Fuzhou 350002, China. xmyu0616@fafu.edu.cn.
16
College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou 350002, China. jxy427@fafu.edu.cn.

Abstract

White tea (WT) is one of six tea types originally derived from Fujian Province, China. White tea is known for its health-promoting properties. However, the neuroprotective and anti-aggregatory properties of WT against the hallmark toxic Alzheimer's protein, Aβ have not been investigated. In this study, WT, green tea (GT), oolong tea (OT) and black tea (BT) were manufactured using tea leaves from the cultivar Camellia sinensis (Jin Guanyin). The protective effects of these tea extracts were then studied under oxidative stress conditions via t-bhp and H2O2 exposure, in addition to Aβ treatment using a PC-12 cell model. Each tea type failed to rescue PC-12 cells from either t-bhp or H2O2-mediated toxicity, however each extract exerted significant protection against Aβ-evoked neurotoxicity. Results of the Thioflavin T Kinetic (ThT) and TEM assay showed that Aβ aggregate formation was inhibited by each tea type. Additionally, TEM also supported the different anti-aggregatory effect of WT by modifying Aβ into an amorphous and punctate aggregate morphology. Higher accumulated precedent or potential neuroprotective compounds in WT, including ECG''3Me, 8-C-ascorbyl-EGCG, GABA and Gln, in addition to flavonol or flavone glycosides detected by using UPLC-QTOF-MS and UPLC-QqQ-MS, may contribute to a favourable anti-aggregative and neuroprotective effect of WT against Aβ.

KEYWORDS:

Alzheimer’s disease; PC-12 cell; UPLC-QTOF-MS; UPLC-QqQ-MS; amyloid β; chemical profiles; oxidative stress; white tea

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