The Notch ligand DLL1 exerts carcinogenic features in human breast cancer cells

PLoS One. 2019 May 20;14(5):e0217002. doi: 10.1371/journal.pone.0217002. eCollection 2019.

Abstract

These findings provide further evidence that DLL1 exerts carcinogenic effects in BC cells. The dissimilar effects of DLL1 downregulation observed amongst MCF-7, BT474, and MDA-MB-231 cells is likely due to their distinctive genetic and biologic characteristics, suggesting that DLL1 contributes to BC through various mechanisms.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apoptosis / genetics
  • Breast Neoplasms / genetics*
  • Breast Neoplasms / pathology
  • Calcium-Binding Proteins / genetics*
  • Carcinogenesis / genetics*
  • Cell Cycle / genetics
  • Cell Division / genetics
  • Cell Proliferation / genetics
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • MCF-7 Cells
  • Membrane Proteins / genetics*
  • RNA, Small Interfering / genetics
  • Receptors, Notch / genetics*
  • Transfection

Substances

  • Calcium-Binding Proteins
  • DLK1 protein, human
  • Membrane Proteins
  • RNA, Small Interfering
  • Receptors, Notch

Grants and funding

This work was supported by “Fundação para a Ciência e Tecnologia”, Portugal, grants PTDC/BBB-BMD/4497/2014 (to AB) and PD/BD/113987/2015 (to JSD). iNOVA4Health - UID/Multi/04462/2019, a program financially supported by Fundação para a Ciência e Tecnologia / Ministério da Educação e Ciência, through national funds and co-funded by FEDER under the PT2020 Partnership Agreement is acknowledged. Ana Barbas is employed by Bayer Portugal. Bayer Portugal provided support in the form of salary for author AB, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific role of this author is articulated in the ‘author contributions’ section.