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IEEE Trans Nanobioscience. 2019 Jul;18(3):482-489. doi: 10.1109/TNB.2019.2917814. Epub 2019 May 20.

Type-2 Fuzzy PCA Approach in Extracting Salient Features for Molecular Cancer Diagnostics and Prognostics.


Machine learning is becoming a powerful tool for cancer diagnosis and prognosis based on classification using high dimensional molecular data. However, extracting classification features from high-dimensional datasets remains a challenging problem. Principal component analysis (PCA) is a widely used method for dimensionality reduction. However, it is well-known that PCA and most PCA-based feature extraction methods are sensitive to noise, which may affect the accuracy of the subsequent classification. To address this problem, here we have proposed a robust fuzzy principal component analysis (PCA) with interval type-2 (IT-2) fuzzy membership functions for feature extraction. We have tested the performance of three widely used classifiers using the features extracted by proposed approaches and other feature extraction methods - PCA-based feature extraction methods (i.e. conventional PCA and fuzzy PCA), linear discriminant analysis (LDA), and support vector machine recursive feature elimination (SVM-RFE). The proposed feature extraction approaches showed better performance on cancer transcriptome and proteome datasets.

[Indexed for MEDLINE]

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