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J Diet Suppl. 2019 May 20:1-17. doi: 10.1080/19390211.2019.1600096. [Epub ahead of print]

Randomized Study of the Effect of Vitamin D and Omega-3 Fatty Acids Cosupplementation as Adjuvant Chemotherapy on Inflammation and Nutritional Status in Colorectal Cancer Patients.

Author information

1
a Department of Nutrition, Nutrition and Metabolic Diseases Research Center , Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran.
2
b Department of Nutrition, Faculty of Paramedicine , Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran.
3
c Tehran University of Medical Sciences , Tehran , Iran.
4
d Faculty of Public Health , Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran.
5
e Department of Nutrition, School of Public Health , Iran University of Medical Sciences , Tehran , Iran.
6
f Pediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences , Tehran , Iran.

Abstract

This study aimed to evaluate the effects of vitamin D3 and omega-3 fatty acids cosupplementation on inflammation and nutritional status in colorectal cancer patients. In this clinical trial, 81 colorectal cancer patients were randomly assigned into four groups: (1) control group: receiving a vitamin D3 placebo weekly + omega-3 fatty acid placebo capsules daily; (2) omega-3 fatty acid group: receiving 2 omega-3 fatty acid capsules (each capsule containing 330 mg of omega-3 fatty acids) daily + a vitamin D3 placebo weekly; (3) vitamin D group: receiving a 50,000 IU vitamin D3 soft gel weekly + 2 omega-3 fatty acid placebo capsules daily; (4) cosupplementation group: receiving a 50,000 IU vitamin D3 soft gel weekly + 2 omega-3 fatty acids capsules daily for 8 weeks. Before and after the intervention, height, weight, fat-free mass (FFM), serum levels of 25(OH)D, tumor necrosis factor alpha (TNF-α), and interleukin 6 (IL-6), C-reactive protein (CRP), and albumin, were measured. After 8 weeks of intervention, patients who received combined vitamin D3 and omega-3 fatty acids supplements compared with omega-3, vitamin D3, and placebo groups had significantly decreased CRP and TNF-α. In addition, serum level of IL-6 was decreased significantly in omega-3, vitamin D3, and cosupplementation groups compared with baseline. Regarding nutritional status, weight, BMI, and FFM% were increased significantly in vitamin D3, omega-3, and cosupplementation groups at the end of the intervention. Vitamin D3 plus omega-3 fatty acids cosupplementation in colorectal cancer patients has beneficial impacts on inflammation and nutritional status.

KEYWORDS:

colorectal cancer; inflammatory biomarkers; nutritional status; omega-3 fatty acids; vitamin D

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