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Food Nutr Res. 2019 May 9;63. doi: 10.29219/fnr.v63.3410. eCollection 2019.

VMP35 MNC, a novel iron-free supplement, enhances cytoprotection against anemia in human subjects: a novel hypothesis.

Author information

1
Brain Restoration Clinic, A Division of Integra Wellness Center, Indian Land, SC, USA.
2
Victory Nutrition International, Inc., Department of R&D, Lederach, PA, USA.
3
ALM R&D, Oldsmar, FL, USA.
4
Veritas Health Inc., Woodbridge, ON, Canada.
5
Department of Pharmacological & Pharmaceutical Sciences, University of Houston college of Pharmacy, Houston, TX, USA.
6
Dr. Herbs LLC, R&D, Concord, CA, USA.

Abstract

Background:

The American Society of Hematology reported that according to the National Heart, Lung, and Blood Institute (NHLBI) anemia is the most common blood disorder, which affects more than 3 million Americans, while the Global Burden of Disease 2016 (GBD 2016) reported that iron deficiency anemia (IDA) is the leading cause of anemia, which affects 1.93 billion people worldwide. Anemia is intricately linked to chronic inflammation, chronic kidney disease, gastrointestinal and gynecological malignancies, and autoimmune disorders. Hemorrhagic anemia results in substantial loss of blood, which causes significant alterations in all blood parameters, including reduced iron. The other type of anemia is chronic anemia syndrome (CAS), which is a constellation of disorders and chronic inflammatory events caused by an increasing anaerobic/acidic environment (promoting the growth of anaerobic organisms), inducing a defensive expenditure of alkalinizing buffers in hemoglobin (i.e. histidine), to prevent a dangerous lowering of blood pH. In this process, iron is cleaved from heme groups and transferred out of blood circulation into other organs, like the liver, appearing to be IDA, where excessive accumulation can lead to hemochromatosis, also known as 'iron overload anemia'.

Design:

A pilot clinical study was conducted in 38 subjects (men = 10; women = 28; age = 22-82 years) to evaluate the rate of absorption and effects on blood of VMP35 multi-nutrient complex (MNC), a non-iron containing liquid nutraceutical supplement. Subjects consumed either placebo or VMP35 (30 mL) over a period of 0, 5, or 30 min.

Methods:

Changes in peripheral blood smears from 38 subjects were observed using live blood cell imaging (LBCI) with phase contrast microscopy. Adverse events were rigorously monitored.

Results:

VMP35 caused positive changes in the blood, including morphological, hematological (including restoration of hemoglobin), and rheological changes following 5 min of administration, which were sustained for at least 30 min.

Conclusion:

Overall, the non-iron containing VMP35 can induce improvements in blood properties and potential benefits for subjects even with compromised digestive systems. No adverse events were reported. Further research studies are in progress to explore the mechanistic insight.

KEYWORDS:

VMP35; a liquid multi-nutrient complex; anemia; hematology; human subjects; live blood cell imaging; morphology; rheology; safety

Conflict of interest statement

JRC is a highly respected board-certified practicing medical doctor whose clinical experience with the VMP35 confirmed the concept and hypothesis of this article and guided the writing of the manuscript. BWD, DB and SK contributed to the concept of the manuscript and are engaged with Victory Nutrition International, Inc., Lederach, PA, and ALM R&D, Oldsmar, FL, respectively. TA is an integral part of Veritas Health Inc., Woodbridge, ON, who organized the live cell imaging procedures. MB (Dr. Herbs LLC, Concord, CA) is an independent consultant, who compiled the data and routed the manuscript to all concerned.

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