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Trends Biotechnol. 2019 May 16. pii: S0167-7799(19)30086-1. doi: 10.1016/j.tibtech.2019.04.008. [Epub ahead of print]

Recent Advances in Biosensors for Detecting Cancer-Derived Exosomes.

Author information

1
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, PR China; School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164, USA.
2
School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164, USA.
3
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, PR China.
4
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, PR China. Electronic address: xuwentao@cau.edu.cn.
5
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, PR China. Electronic address: lyb@cau.edu.cn.
6
School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164, USA. Electronic address: yuehe.lin@wsu.edu.

Abstract

Early detection and effective treatments are two of the greatest challenges in the fight against cancer. Cancer-derived exosomes are attractive biomarkers for the early diagnosis and therapeutic response evaluation of cancer. Here, we review recent advances in biosensors for the detection of cancer-derived exosomes. We discuss the potential exosomal biomarkers of various cancers, which can be applied as indicative targets in the design of biosensors. We further describe the fabrication of exosome detection biosensors with respect to biological recognition strategies and signal transduction techniques, which involve integrated scientific and technological aspects of analytical chemistry and nanotechnology. Furthermore, future research directions and challenges in using cancer-derived exosomes for point-of-care (POC) testing are presented.

KEYWORDS:

biosensor; cancer biomarker; detection; exosome; nanomaterials

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