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Am J Ophthalmol. 2019 May 16. pii: S0002-9394(19)30232-6. doi: 10.1016/j.ajo.2019.05.012. [Epub ahead of print]

Is Myopia associated with the Incidence and Progression of Diabetic Retinopathy?

Author information

1
Singapore Eye Research Institute, Singapore; Duke-NUS Medical School, Singapore.
2
Singapore Eye Research Institute, Singapore.
3
University of Sydney, Australia.
4
Singapore Eye Research Institute, Singapore; Duke-NUS Medical School, Singapore; Singapore National Eye Centre, Singapore; National University of Singapore, Singapore.
5
Singapore Eye Research Institute, Singapore; Duke-NUS Medical School, Singapore; National University of Singapore, Singapore. Electronic address: ecosse.lamoureux@seri.com.sg.

Abstract

PURPOSE:

To determine the association of refractive error (RE) and its associated determinants (axial length [AL], anterior chamber depth (ACD) and corneal curvature [CC]) with the incidence and progression of diabetic retinopathy (DR).

DESIGN:

Population-based cohort study METHODS: A total of 1562 eyes of 840 individuals with diabetes and gradable retinal photographs (mean age [SD]: 57.0 [8.3] years, 48.2% female), from the Singapore Malay and Indian Eye Studies, at baseline (2004-2009) and follow-up (2011-2015) examinations were included in analyses. RE was calculated as sphere plus half negative cylinder, while AL, ACD and CC were assessed using optical biometry. Incident DR was defined as having no baseline DR and any DR at follow-up; incident vision-threatening DR (VTDR) as no baseline VTDR but present at follow-up; and DR progression as an increase in severity at follow-up from at least minimal baseline DR. Eye-specific data and generalized estimating equation models to account for between-eye correlation were utilized to determine the relationships between the exposures and outcomes, adjusted for traditional DR risk factors.

RESULTS:

At follow-up, 164 of 1273 (12.9%) had incident DR, 17 of 1542 (1.1%) eyes had incident VTDR, and 75 of 269 (27.9%) eyes with baseline DR experienced progression. A longer AL (per mm increase, risk ratio, 95% confidence interval: 0.58, 0.38, 0.88) was associated with lower risk of incident DR. No other associations were found.

CONCLUSION:

Our findings show that a longer AL is protective of incident DR.

PMID:
31103525
DOI:
10.1016/j.ajo.2019.05.012

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