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Neurobiol Learn Mem. 2019 Jul;162:47-58. doi: 10.1016/j.nlm.2019.04.014. Epub 2019 May 16.

Impaired social discrimination behavior despite normal social approach by kallikrein-related peptidase 8 knockout mouse.

Author information

1
Department of Functional Anatomy and Neuroscience, Asahikawa Medical University, Asahikawa, Hokkaido 078-8510, Japan. Electronic address: h-nakazawa@asahikawa-med.ac.jp.
2
Department of Systems Life Engineering, Maebashi Institute of Technology, Maebashi, Gunma 371-0816, Japan.
3
Department of Anatomy, Akita University Graduate School of Medicine, Akita, Akita 010-8543, Japan.
4
Department of Functional Anatomy and Neuroscience, Asahikawa Medical University, Asahikawa, Hokkaido 078-8510, Japan.
5
Graduate School of Biological Science, Nara Institute of Science and Technology (NAIST), Ikoma, Nara 630-0192, Japan. Electronic address: shiosaka-s@bs.naist.jp.

Abstract

For social mammals, recognition of conspecifics and discrimination of each other (social memory) is crucial to living in a stable colony. Here, we investigated whether kallikrein-related peptidase 8 (KLK8)-neuregulin 1 (NRG1)-ErbB signaling is crucial for social discrimination behavior using the social discrimination three chamber behavioral test. Klk8 knockout mice (NRG1-deactivated mice) exhibited normal social approach but impaired social discrimination. Intraventricular injection of recombinant NRG1177-246 into Klk8 knockout mice reversed this impaired social discrimination. This study reveals that KLK8 is a key regulator of NRG1-ErbB signaling, which contributes to social discrimination behavior.

KEYWORDS:

Hippocampus; KLK8; NRG1-ErbB signaling; Social discrimination; Social memory

PMID:
31103466
DOI:
10.1016/j.nlm.2019.04.014

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