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Neuron. 2019 Jul 3;103(1):147-160.e8. doi: 10.1016/j.neuron.2019.04.020. Epub 2019 May 15.

A Flexible Model of Working Memory.

Author information

1
Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08540, USA.
2
Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08540, USA; Department of Psychology, Princeton University, Princeton, NJ 08540, USA. Electronic address: tbuschma@princeton.edu.

Abstract

Working memory is fundamental to cognition, allowing one to hold information "in mind." A defining characteristic of working memory is its flexibility: we can hold anything in mind. However, typical models of working memory rely on finely tuned, content-specific attractors to persistently maintain neural activity and therefore do not allow for the flexibility observed in behavior. Here, we present a flexible model of working memory that maintains representations through random recurrent connections between two layers of neurons: a structured "sensory" layer and a randomly connected, unstructured layer. As the interactions are untuned with respect to the content being stored, the network maintains any arbitrary input. However, in our model, this flexibility comes at a cost: the random connections overlap, leading to interference between representations and limiting the memory capacity of the network. Additionally, our model captures several other key behavioral and neurophysiological characteristics of working memory.

KEYWORDS:

capacity limitations; cognitive control; cognitive flexibility; computational model; excitation-inhibition balance; mixed selectivity; working memory

PMID:
31103359
PMCID:
PMC6613943
[Available on 2020-07-03]
DOI:
10.1016/j.neuron.2019.04.020

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