Format

Send to

Choose Destination
Stem Cell Res. 2019 May 9;38:101460. doi: 10.1016/j.scr.2019.101460. [Epub ahead of print]

Generation of refractory schizophrenia patient-derived induced pluripotent stem cell line UJSi001-A.

Author information

1
Neurobiology & Mitochondrial Key Laboratory, School of Pharmacy, Jiangsu University, Zhenjiang 212013, PR China. Electronic address: sjyancheng@ujs.edu.cn.
2
Neurobiology & Mitochondrial Key Laboratory, School of Pharmacy, Jiangsu University, Zhenjiang 212013, PR China.
3
Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Bio-X Institutes, Shanghai Jiao Tong University, Shanghai 200030, PR China.
4
Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 201100, PR China.
5
Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Bio-X Institutes, Shanghai Jiao Tong University, Shanghai 200030, PR China. Electronic address: chinsir@sjtu.edu.cn.

Abstract

Schizophrenia is considered one of the most serious mental disorders nowadays. Approximately 30-60% of people with schizophrenia do not present adequate response to drug treatment and persist with symptoms of the disease; they are known as refractory schizophrenic people. We generated induced pluripotent stem cells (iPSCs) from a refractory schizophrenia patient by electroporation of peripheral blood mononuclear cells (PBMC) with episomal plasmids encoding OCT 4, SOX 2, NANOG, LIN 28, KLF 4 and LMYC. The resulting iPSCs had normal karyotype, were free of genomically integrated episomal plasmids, expressed pluripotency markers, and could differentiate into the three germ layers in vivo.

PMID:
31102833
DOI:
10.1016/j.scr.2019.101460
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center