Format

Send to

Choose Destination
Diabetes Res Clin Pract. 2019 Jun;152:156-165. doi: 10.1016/j.diabres.2019.05.009. Epub 2019 May 15.

The beneficial effects of 15 units of high-intensity circuit training in women is modified by age, baseline insulin resistance and physical capacity.

Author information

1
Gdansk University of Physical Education and Sport, Faculty of Physical Education, Department of Anatomy and Anthropology, Poland.
2
Gdansk University of Physical Education and Sport, Faculty of Rehabilitation and Kinesiology, Department of Physiology and Pharmacology, Poland.
3
Gdansk University of Physical Education and Sport, Faculty of Physical Education, Department of Life Sciences, Poland.
4
Gdansk University of Physical Education and Sport, Faculty of Rehabilitation and Kinesiology, Department of Health Promotion and Posturology, Poland.
5
Gdansk University of Physical Education and Sport, Faculty of Rehabilitation and Kinesiology, Department of Physiotherapy, Poland.
6
Gdansk University of Physical Education and Sport, Faculty of Rehabilitation and Kinesiology, Department of Physiology and Pharmacology, Poland. Electronic address: ziemann.ewa@gmail.com.

Abstract

AIM:

To investigate the effect of a single and 15 units of high-intensity circuit training (HICT) programme on glucose metabolism, myokines' response and selected genes' expression in women.

METHODS:

Thirty-three, non-active women (mean age: 38 ± 12) were split into a HICT (n = 20) or a control group (CON, n = 13). The training protocol included three circuits of nine exercises with own body weight as a workload performed 3 times a week for five weeks. The CON group performed HICT twice. Blood samples were taken before, 1 h and 24 h after the first and last unit to determine IGF-1, myostatin, irisin, decorin, HSP27, interleukin-15 concentrations using the ELISA immunoenzymatic method. To evaluate HSPB1, TNF-α and DCN mRNA, real-time PCR was used. Pre- and post-intervention, the oral glucose test and body composition assessment were completed.

RESULTS:

The following parameters tended to decrease after the 5-week HICT program: insulin and HOMA-IR Training diminished insulin/IGF-1 ratio (51% CI: -63% to -34%) and induced the drop of myostatin concentration but significantly only among middle-aged women and at baseline insulin resistance.

CONCLUSION:

Obtained data revealed that HICT improved an insulin sensitivity and diminished myostatin concentration among older, insulin-resistant women with lower baseline physical capacity.

KEYWORDS:

Decorin; Heat shock protein; Insulin growth factors; Insulin resistance; Oral glucose tolerance test

PMID:
31102684
DOI:
10.1016/j.diabres.2019.05.009
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center