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Neurochem Res. 2019 May 17. doi: 10.1007/s11064-019-02816-2. [Epub ahead of print]

Silibinin Alleviates the Learning and Memory Defects in Overtrained Rats Accompanying Reduced Neuronal Apoptosis and Senescence.

Author information

1
Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, People's Republic of China.
2
Medical Research Center, Shenzhen University Health Science Center, Shenzhen, 518060, People's Republic of China.
3
Department of Chemistry and Life Science, School of Advanced Engineering, Kogakuin University, 2665-1 Nakanomachi, Hachioji, Tokyo, 192-0015, Japan.
4
Medical Research Institute of Curing Mibyo, 1-6-28 Narusedai, Mechida, Tokyo, 194-0042, Japan.
5
Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, People's Republic of China. ikejimat@vip.sina.com.
6
Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, People's Republic of China. ikejimat@vip.sina.com.

Abstract

Excessive physical exercise (overtraining; OT) increases oxidative stress and induces damage in multiple organs including the brain, especially the hippocampus that plays an important role in learning and memory. Silibinin, a natural flavonoid derived from milk thistle of Silybum marianum, has been reported to exert neuroprotective effect. In this study, rats were subjected to overtraining exercise, and the protective effects of silibinin were investigated in these models. Morris water maze and novel object recognition tests showed that silibinin significantly attenuated memory defects in overtrained rats. At the same time, the results of Nissl, TUNEL and SA-β-gal staining showed that silibinin reversed neuronal loss caused by apoptosis, and delayed cell senescence of the hippocampus in the overtrained rats, respectively. In addition, silibinin decreased malondialdehyde (MDA) levels which is associated with reactive oxygen species (ROS) generation. Silibinin prevented impairment of learning and memory caused by excessive physical exercise in rats, accompanied by reduced apoptosis and senescence in hippocampus cells.

KEYWORDS:

Apoptosis; Hippocampus; Overtraining; Senescence; Silibinin

PMID:
31102026
DOI:
10.1007/s11064-019-02816-2

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