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Chemistry. 2019 Sep 12;25(51):11797-11819. doi: 10.1002/chem.201901840. Epub 2019 Jul 8.

Fluorine-Containing Drugs Approved by the FDA in 2018.

Author information

1
College of Chemical Engineering, Nanjing Forestry University, Nanjing, 210037, China.
2
Departamento de Química Orgánica, Universidad de Valencia, 46100 Burjassot, Valencia, Spain.
3
Laboratorio de Moléculas Orgánicas, Centro de Investigación Príncipe Felipe, 46012, Valencia, Spain.
4
Department of Phrmaceutical Sciences, University of Perugia, Via del Liceo 1, 06123, Perugia, Italy.
5
Department of Chemistry, Biology and Biotechnologies, University of Perugia, Via Elce di Sotto 8, 06123, Perugia, Italy.
6
Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardizábal 3, 20018, San Sebastián, Spain.
7
IKERBASQUE, Basque Foundation for Science, María Díaz de Haro 3, Plaza Bizkaia, 48013, Bilbao, Spain.

Abstract

Over the last two decades, fluorine substitution has become one of the essential structural traits in modern pharmaceuticals. Thus, about half of the most successful drugs (blockbuster drugs) contain fluorine atoms. In this review, we profile 17 fluorine-containing drugs approved by the food and drug administration (FDA) in 2018. The newly approved pharmaceuticals feature several types of aromatic F and CF3 , as well as aliphatic (CF2 ) substitution, offering advances in the treatment of various diseases, including cancer, HIV, malarial and smallpox infections.

KEYWORDS:

HIV; biochemistry; cancer; fluorine; substitution reactions

PMID:
31099931
DOI:
10.1002/chem.201901840
[Indexed for MEDLINE]

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