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Aesthet Surg J. 2019 May 16. pii: sjz145. doi: 10.1093/asj/sjz145. [Epub ahead of print]

A 3-Dimensional Quantitative Analysis of Volume Loss Following Submental Cryolipolysis.

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Department of Plastics and Reconstructive Surgery, Bendigo Health, Bendigo, Australia.
Monash University, Bendigo, Australia.
Private Practice in Bendigo, Australia.



Cryolipolysis is a proven and effective means of fat reduction; however, there are no standardized means of measuring volume reduction.


We aim to assess the volume loss using a 3-dimensional (3D) analysis following submental cryolipolysis.


A retrospective cohort study between April 2016-August 2018 was performed. Thirty-five patients underwent a single 45-minute cycle of cryolipolysis to the submental region using the CoolSculpting System. A three-fold analysis was performed using an independent observer assessment of 2D photographs and 3D volumetric analysis using the Vectra XT system, and patient satisfaction was measured using the FACE-QTM questionnaire.


Our results suggested the mean (SD) pretreatment volume (n=35) was 104.12 cm3 (28.78). The 6-week mean posttreatment volume (n=26) was 81.55 cm3 (21.29). The mean volume reduction found at 6 weeks posttreatment showed a reduction of 22.46 cm3 (19.10) (95% CI 14.74 to 30.17), P<0.0001. The 12-week mean posttreatment volume (n=24) was 82.24 cm3 (23.97). The 12-week posttreatment demonstrated a reduction of 22.30 cm3 (14.04) (95% CI 16.37 to 28.23), P<0.0001. The mean percentage correct for each reviewer correctly identifying the pretreatment and posttreatment photograph was 76.33% (7.14). Patient satisfaction showed a mean FACE-Q score was 54.10 (20.41).


The study further affirms that submental cryolipolysis is an efficacious and safe, noninvasive method for reducing submental adiposity resulting in notable patient satisfaction rates. Furthermore, results suggest that patients can have a volume loss of about 20% on average, allowing them to be more confident and comfortable with their appearance.


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