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Curr Alzheimer Res. 2019 May 17. doi: 10.2174/1567205016666190517121140. [Epub ahead of print]

Biomarkers for Alzheimer´s disease.

Author information

1
Laboratory of Neurosciences, International Center for Biomedicine (ICC). Chile.
2
Clinical Hospital, University of Chile. Chile.

Abstract

Alzheimer´s disease (AD) and related dementias are impacting the aging population throughout the world, at an alarming rate. World Alzheimer´s Report indicates a prevalence of 46.8 million affected with AD worldwide. As population ages, this number is projected to triple by 2050 unless effective interventions can be developed and implemented. Urgent efforts are required for an early detection of this disease. The ultimate goal is the identification of viable targets for the development of molecular markers and validation of their use for early diagnosis of AD that may improve treatment and the disease outcome in patients. The diagnosis of AD has been difficult to resolve since approaches for early and accurate detection and follow-up of AD patients at the clinical level have been reported only recently. Proposed AD biomarkers include detection of pathophysiological processes in the brain in vivo with new imaging techniques and novel PET ligands, and determination of pathogenic proteins in cerebrospinal fluid showing anomalous levels of hyperphosphorylated tau and low Aβ peptide. These biomarkers have been increasingly accepted by AD diagnostic criteria and are important tools for the design of clinical trials, but difficulties in accessibility to costly and invasive procedures is not fully solved in clinical settings. New biomarkers are currently being developed to allow determinations of multiple pathological processes including neuroinflammation, synaptic dysfunction, metabolic impairment, protein aggregation and neurodegeneration. Highly specific and sensitive blood biomarkers, using less-invasive procedures to detect AD, derives from the discoveries of peripheric tau oligomers and amyloid variants in human plasma and platelets. We have also developed a blood tau biomarker that correlates with cognitive decline and also with neuroimaging determinations of brain atrophy.

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