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Lung Cancer. 2019 Jun;132:24-27. doi: 10.1016/j.lungcan.2019.03.023. Epub 2019 Mar 31.

The role of radiation treatment in pleural mesothelioma: Highlights of the 14th International Conference of the International mesothelioma interest group.

Author information

1
Division of Radiation Oncology, The Ottawa Hospital, Ottawa, Ontario, Canada. Electronic address: rmacrae@toh.ca.
2
Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom.
3
Department of Thoracic Surgery, University Hospital Zürich, Zürich. Switzerland.
4
Medical School, University of Western Australia / National Centre for Asbestos Related Diseases, Perth, WA, Australia.
5
Department of Radiation Oncology, University of Maryland School of Medicine, USA.
6
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Centre, New York, USA.

Abstract

Radiation remains an important component of mesothelioma treatment in 2018. Its use as a treatment modality continues to evolve as the technology for planning and delivery continues to improve. Use of radiation to improve local control in the involved hemithorax has been a common adjuvant treatment post extrapleural pneumonectomy for many years. Modern treatment options with advanced planning techniques including protons and intensity modulated radiation therapy lead to new potential options for treatment post lung-sparing surgery or in the unresectable setting. Presentations and discussions on the implementation of these strategies for palliation, treatment of oligometastatic recurrence or unresectable disease were the focus of a session dedicated to the role of radiation therapy at the 14th International Conference of the International Mesothelioma Interest Group and are reviewed in this article. Preclinical data to better understand how to integrate radiation and the delivery of novel systemic therapy approached like check point inhibitors are also presented.

KEYWORDS:

Mesothelioma; Palliation; Radiation; Radiotherapy

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