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Epilepsia. 2019 Jun;60(6):1150-1159. doi: 10.1111/epi.15457. Epub 2019 May 16.

Symptomatogenic zone and network of oroalimentary automatisms in mesial temporal lobe epilepsy.

Author information

1
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
2
Beijing Key Laboratory of Neurostimulation, Beijing, China.
3
Epilepsy Center, Peking University First Hospital Fengtai Hospital, Beijing, China.
4
Stereotactic and Functional Neurosurgery Laboratory, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
5
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Abstract

OBJECTIVE:

Oroalimentary automatisms (OAAs) are common clinical manifestations of medial temporal lobe epilepsy. Nevertheless, the location of the symptomatogenic zone of OAAs remains unclear. The generation mechanism of OAAs also has not been clarified. We attempt to explain these problems by analyzing interictal [18 F]-fluorodeoxyglucose positron emission tomography (18 FDG-PET) imaging and ictal stereo-electroencephalography (SEEG) recordings in patients with medial temporal lobe epilepsy.

METHODS:

Fifty-seven patients with mesial temporal lobe epilepsy were analyzed retrospectively. All underwent anterior temporal lobectomy (ATL) and were seizure-free. The patients were divided into OAA (+) and OAA (-) groups according to the occurrence of consistent stereotyped OAAs. The interictal PET data were compared with those of 18 healthy controls and were then compared between groups using statistical parametric mapping (SPM). Functional connectivity using linear regression analysis was performed between the target brain regions. To clarify the network of OAAs, ictal epileptogenicity index (EI) values, and the nonlinear correlation method h2 were performed with SEEG on patients.

RESULTS:

Compared to OAAs (-), the rolandic operculum was the only area with significant differences. Hippocampus and rolandic operculum showed significant correlations in the OAA (+) group (y = 0.758x+0.470, R2  = 0.456, P = 0.000). No correlation was found in the OAA (-) group (P = 0.486). The EI values of the OAA (+) group (median 0.20) were significantly higher (P < 0.0001) than those of the OAA (-) group (median 0). The h2 in the OAA (+) group (h2  = 0.23 ± 0.13) showed stronger functional connectivity (t = 6.166, P < 0.0001) than that of the OAA (-) group (h2  = 0.08 ± 0.05).

SIGNIFICANCE:

The rolandic operculum is most likely to be the symptomatogenic zone of OAAs. In medial temporal lobe epilepsy, unilateral functional connection from the hippocampus to the rolandic operculum during seizure onset is the basis for the generation of OAAs.

KEYWORDS:

PET analysis; epileptogenicity index; functional connectivity; oroalimentary automatisms; symptomatogenic zone

PMID:
31095733
DOI:
10.1111/epi.15457

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