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IEEE Trans Med Imaging. 2019 May 13. doi: 10.1109/TMI.2019.2916326. [Epub ahead of print]

Development of Positron Emission Tomography with Wobbling and Zooming for High Sensitivity and High-Resolution Molecular Imaging.


Demands for in-vivo human molecular imaging with high resolution and high sensitivity in PET require several new design formulae. A classical problem of positron emission tomography (PET) design, however, was the trade-off between sensitivity and resolution. To satisfy both requirements, the brain-body convertible PET with wobbling and zooming is proposed. The features of this new proposed system are wobble sampling for high-resolution imaging and zooming mode for high sensitivity, especially for the brain dedicated imaging. For the high resolution, wobbling with linear interpolation and line spread function (LSF) deconvolution reconstruction algorithm was introduced. The result of the proposed system provided resolution up to 1.56 mm full width at half maximum (FWHM) in the brain mode and resulting the detector-to-resolution ratio (DRR) was 2.47. For both brain phantom and in-vivo rat brain imaging, the proposed system demonstrated superior image quality compared to the commercial PET systems. The newly designed PET with wobbling and zooming also demonstrated the possibility of developing practically usable high resolution human brain PET-MRI fusion system, especially for the neuroscience research.


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